Dr. Cory Yamashita, MD, FRCPC

Yamashita

Rank / Affiliations

  • Division Chair
  • Program Director
  • Associate Professor
  • Lawson Health Research Institute (LHRI), Scientist

Training

  • Undergraduate, University of Manitoba
  • MD, University of Manitoba
  • Internal Medicine, Western University
  • Respirology, Western University
  • Research Fellowship, Acute Lung Injury, Western University
  • Research Fellowship, Lung Injury & Repair, National Jewish Health, Denver, CO

Clinical Interest

  • General Respirology
  • Asthma

Research Interest

  • Antimicrobial Peptides/ Pulmonary Surfactant
  • Mechanisms of Acute Lung Injury and Multiple Organ Failure
  • Severe Asthma

Awards

  • Parker B. Francis Foundation Fellowship (2009-2012)
  • Honour Roll Certificate, University Students’ Council, The University of Western Ontario Excellence in Teaching Undergraduate Medical Education, 2011-13
  • Honour Roll Certificate, University Students' Council, Undergraduate, Department of Physiology & Pharmacology, 2012
  • Cystic Fibrosis Canada Robbie Award 2015-16

Selected Publications

Thamboo AV, Lee M, Bhutani M, Chan C, Chan Y, Chapman KR, Chin CJ, Connors L, Dorscheid D, Ellis AK, Gall RM, Godbout K, Janjua A, Javer A, Kilty S, Kim H, Kirkpatrick G, Lee JM, Leigh R, Lemiere C, Monteiro E, Neighbour H, Keith PK, Philteos G, Quirt, Rotenberg JB, Ruiz JC, Scott JR, Sommer DD, Sowerby L, Tewfk M, Waserman S, Witterick I, Wright ED, Yamashita CM and Desrosiers M. Canadian Multidisciplinary Expert Consensus of the Use of Biologics in Upper Airways: a Delphi study. Journal of Otolaryngology - Head & Neck Surgery, 2023 Apr 24; 52 (30). Impact Factor: 4.856, Coauthor

McIntosh MJ, Kooner HK, Eddy RL, Jeimy S, Licskai C, Mackenzie CA, Svenningsen S, Nair P, Yamashita C, Parraga G. Asthma Control, Airway Mucus, and 129Xe MRI Ventilation After a Single Benralizumab Dose. Chest, 2022 Mar 10, Coauthor, DOI: 10.1016/j.chest.2022.03.003.

McIntosh MJ, Biancaniello A, Kooner HK, Bhalla A, Serajeddini H, Yamashita C, Parraga G, Eddy RL. 129Xe MRI Ventilation Defects in Asthma: What is the Upper Limit of Normal and Minimal Clinically Important Difference? Acad Radiol. 2023 Apr 7:S1076-6332(23)00121-6. doi: 10.1016/j.acra.2023.03.010. Coauthor Epub ahead of print. PMID: 37032278.

McIntosh MJ, Kooner HK, Eddy RL, Wilson A, Serajeddini H, Bhalla A, Licskai C, Mackenzie CA, Yamashita C, Parraga G. CT Mucus Score and 129Xe MRI Ventilation Defects After 2.5 Years' Anti-IL-5Rα in Eosinophilic Asthma. Chest. 2023 Feb 11:S0012-3692(23)00189-7. doi: 10.1016/j.chest.2023.02.009. Coauthor Epub ahead of print. PMID: 36781102.

Veldhuizen R, Hardy D, Arany E, Khazaee R, McCAig L, Vinokurtseva A,Yamashita C. The impact of maternal protein restriction during perinatal life on the response to a septic insult in adult rats. Journal of Developmental Origins of Health and Disease, Cambridge, 2020, Pub ID 33353580 DOI: 10.107/52040174420001269 Coauthor

Deschner M, Tunks M, Yamashita C. Electronic Cigarettes, Vaping and Lung Disease. A Short Primer. Canadian Journal of General Internal Medicine, 2020; 15(4), 24-27, Senior Responsible Author 

Deschner M, Parraga G, Yamashita C. COVID-19 and return-to-work recommendations for people with chronic respiratory diseases. CMAJ, 2020; 192(35), E1021, 10.1503/cmaj.76441 Senior Responsible Author pubmed article ID 32868276.

Baer B, Veldhuizen EJA, Molchanova N, Jekhmane S, Weingarth M, Jenssen H, Lin JS, Barron AE, Yamashita C, Velduiszen R. Optimizing Exogenous Surfactant as a Pulmonary Delivery Vehicle for Chicken Cathelicidin-2. Sci Rep, 2020, 10.1038/s41598-020-66448-1, 9392, coauthor, pubmed article ID 32523049

Khazaee R, McCaig LA, Yamashita C, Hardy DB, Veldhuizen RAW. Maternal protein restriction during perinatal life affects lung mechanics and the surfactant system during early postnatal life in female rats. PLoS One, 2019 Jan 1; 14 (4): e0215611, Coauthor, DOI: 10.1371/journal.pone.0215611.

Baer B, Veldhuizen EJA, Possmayer F, Yamashita C, Veldhuizen R. The wet bridge transfer system: a novel tool to assess exogenous surfactant as a vehicle for intrapulmonary drug delivery. Discov Med, 2018 Nov 1; 26 (144): 207-218, Coauthor

Banaschewski BJH, Baer B, Arsenault C, Jazey T, Veldhuizen EJA, Delport J, Gooyers T, Lewis JF, Haagsman HP, Veldhuizen RAW, Yamashita C. The Antibacterial and Anti-inflammatory Activity of Chicken Cathelicidin-2 combined with Exogenous Surfactant for the Treatment of Cystic Fibrosis-Associated Pathogens. Sci Rep, 2017 Nov 14; 7 (1): 15545, Senior Responsible Author, DOI: 10.1038/s41598-017-15558-4.

Coorens M, Banaschewski BJH, Baer BJ, Yamashita C, van Dijk A, Haagsman HP, Veldhuizen RAW, Veldhuizen EJA. Killing of P. aeruginosa by chicken cathelicidin-2 is immunogenically silent, preventing lung inflammation in vivo. Infect Immun, 2017 Sep 25, Coauthor, DOI: 10.1128/IAI.00546-17.

Milos S, Khazaee R, McCaig LA, Nygard K, Gardiner RB, Zuo YY, Yamashita C, Veldhuizen R. Impact of ventilation-induced lung injury on the structure and function of lamellar bodies. Am J Physiol Lung Cell Mol Physiol, 2017 Sep 1; 313 (3): L524-L533, Coauthor, DOI: 10.1152/ajplung.00055.2017.

Sheikh, Khadija, Bhalla, Anurag; Ouriadov, Alexei;  Young, Heather;Yamashita, Cory; Luu, Thuy Katz, Sherry; Parraga, Grace. Pulmonary Magnetic Resonance Imaging Biomarkers of Lung Structure and Function in Adult Survivors of Bronchopulmonary Dysplasia with COPD. Cogent OA, 2017 Jan 24, Coauthor

Puntorieri V, McCaig LA, Howlett CJ, Yao LJ, Lewis JF, Yamashita CM, Veldhuizen RA. Lack of matrix metalloproteinase 3 in mouse models of lung injury ameliorates the pulmonary inflammatory response in female but not in male mice. Exp Lung Res, 2016 Sep 27: 1-15, Coauthor, DOI: 10.1080/01902148.2016.1231243.

Yamashita CM, Cybulskie C, Milos S, Zuo YY, McCaig LA, Veldhuizen RA. The effect of matrix metalloproteinase-3 deficiency on pulmonary surfactant in a mouse model of acute lung injury. Can J Physiol Pharmacol, 2016 Jun 1; 94 (6): 682-5, Principal Author, DOI: 10.1139/cjpp-2015-0377.

Hiansen JQ, Keating E, Aspros A, Yao LJ, Bosma KJ, Yamashita CM, Lewis JF, Veldhuizen RA. Cholesterol-mediated surfactant dysfunction is mitigated by surfactant protein A. Biochim Biophys Acta, 2015 Mar 1; 1848 (3): 813-20. Impact Factor: 3.99, Coauthor, DOI: 10.1016/j.bbamem.2014.12.009.

Banaschewski BJ, Veldhuizen EJ, Keating E, Haagsman HP, Zuo YY, Yamashita CM, Veldhuizen RA. Antimicrobial and biophysical properties of surfactant supplemented with an antimicrobial peptide for treatment of bacterial pneumonia. Antimicrob Agents Chemother, 2015 Jan 1; 59 (6): 3075-83. Impact Factor: 4.6, Coauthor, DOI: 10.1128/AAC.04937-14.

Aschner Y, Zemans RL, Yamashita CM, Downey GP. Matrix metalloproteinases and protein tyrosine kinases: potential novel targets in acute lung injury and ARDS. Chest, 2014 Oct 1; 146 (4): 1081-91. Impact Factor: 6.92, Coauthor, DOI: 10.1378/chest.14-0397.

Yamashita CM, Radisky DC, Aschner Y, Downey GP. The importance of matrix metalloproteinase-3 in respiratory disorders. Expert Rev Respir Med, 2014 Aug 1; 8 (4): 411-21. Impact Factor: 2.28, Principal Author, DOI: 10.1586/17476348.2014.909288.

Radhakrishnan D, Yamashita C, Gillio-Meina C, Fraser DD. Translational research in pediatrics III: bronchoalveolar lavage. Pediatrics, 2014 Jul 1; 134 (1): 135-54. Impact Factor: 5.12, Co-Principal Author, DOI: 10.1542/peds.2013-1911.

Aschner Y, Khalifah AP, Briones N, Yamashita C, Dolgonos L, Young SK, Campbell MN, Riches DW, Redente EF, Janssen WJ, Henson PM, Sap J, Vacaresse N, Kapus A, McCulloch CA, Zemans RL, Downey GP. Protein tyrosine phosphatase α mediates profibrotic signaling in lung fibroblasts through TGF-β responsiveness. Am J Pathol, 2014 May 1; 184 (5): 1489-502. Impact Factor: 5.21, Coauthor, DOI: 10.1016/j.ajpath.2014.01.016.

Yamashita CM, Fessler MB, Vasanthamohan L, Lac J, Madenspacher J, McCaig L, Yao L, Wang L, Puntorieri V, Mehta S, Lewis JF, Veldhuizen RA. Apolipoprotein E-deficient mice are susceptible to the development of acute lung injury. Respiration, 2014 Jan 1; 87 (5): 416-27. Impact Factor: 2.92, Principal Author, DOI: 10.1159/000358438.

Gill SE, Veldhuizen RAW, Yamashita CM. Alveolar Macrophages and Pulmonary Surfactant - More Than Just Friendly Neighbours. OA Biology, 2013 Dec 1, Senior Responsible Author

Patterson EK, Yao LJ, Ramic N, Lewis JF, Cepinskas G, McCaig L, Veldhuizen RA, Yamashita CM. Lung-derived mediators induce cytokine production in downstream organs via an NF-κB-dependent mechanism. Mediators Inflamm, 2013 Jan 1; 2013: 586895. Impact Factor: 3.26, Senior Responsible Author, DOI: 10.1155/2013/586895.

Contact Information

St. Joseph's Health Care London

268 Grosvenor Street

London, Ontario

N6A 4V2

Phone: (519) 646-6288

Fax: (519) 646-6404