Dr. Sean Gill, PhD

Gill

Rank/ Affiliations:

  • Assistant Professor
  • Cross Appointment, Department of Physiology & Pharmacology
  • Lawson Health Research Institute

Training:

  • Undergraduate, University of Western Ontario
  • PhD, University of Western Ontario
  • Post-doctoral Fellowship, Lung Development, University of Western Ontario
  • Post-doctoral Fellowship, Lung Injury & Inflammation, University of Washington

Research Interest:

  • My lab investigates the molecular mechanisms regulating microvascular endothelial cell dysfunction as well as the initiation and resolution of inflammation during lung injury. Specifically, we focus on the roles of two different families of enzymes – the metalloproteinases, a family of zinc dependent extracellular enzymes, and the caspases, a family of intracellular cysteine proteases.
  • Additional projects include examining how factors such as aging and exercise impact the development and severity of lung injury.
  • Key Words: TIMPs, metalloproteinases, caspases, sepsis, lung injury, microvascular permeability, aging, innate immunity

Research Funding:

  • Canadian Institutes of Health Research
  • Heart and Stroke Foundation of Canada
  • Lawson Health Research Institute
  • Natural Sciences and Engineering Research Council of Canada
  • Ontario Thoracic Society
  • Program of Experimental Medicine, Department of Medicine, University of Western Ontario
  • University of Western Ontario

Awards:

  • 2017 Breathe New Life Award, Ontario Thoracic Society, Toronto, ON
  • 2014 American Society of Matrix Biology (ASMB) Junior Investigator Awardee, ASMB, Bethesda, MD
  • Parker B. Francis Fellowship (2010-2013)

Publications (From the Last 5 Years):

 

  1. Veldhuizen R.A.W., McCaig L.A., Pape M.C., and Gill S.E. (2019) The effects of aging and exercise on lung mechanics, surfactant, and alveolar macrophages. Exp Lung Res. 45(5-6):113-122.
  2. Wang L., Chung J., Gill S.E.*, and Mehta S.* (2019) Quantification of adherens junction disruption and contiguous paracellular protein leak in human lung endothelial cells under septic conditions. Microcirculation. e12528. 26(3): e12528.
  3. Mehta S. and Gill S.E. (2019) Improving Clinical Outcomes in Sepsis and Multiple Organ Dysfunction through Precision Medicine. J Thorac Dis. 11(1): 21-28.
  4. Jayawardena D.P., Kulkarni N.P., and Gill S.E. (2019) The role of tissue inhibitors of metalloproteinases in microvascular endothelial cell barrier dysfunction during sepsis. Metalloproteinases Med. 6: 1-12.
  5. Wang L., Mehta S., Ahmed Y., Wallace S., Pape M.C., and Gill S.E. (2018) Differential Mechanisms of Septic Human Pulmonary Microvascular Endothelial Cell Barrier Dysfunction Depending on the Presence of Neutrophils. Front Immunol. 9: 1-15.
  6. Januzi L., Poirier J.W., Maksoud M.J.E., Xiang Y., Veldhuizen R.A.W., Gill S.E., Cregan S.P., Zhang H., Dekaban G.A., and Lu W. (2018) Autocrine GABA signaling distinctively regulates phenotypic activation of mouse pulmonary macrophages. Cell Immunol. 323: 7-23.
  7. Tyml K., Swarbreck S., Secor D., Pape C., Koropatnick J., Feng Q., Veldhuizen R.A.W., and Gill S.E. (2017) Moderate running protects against early sepsis-induced inflammatory response in aged mice. Crit Care. 21(1): 210.
  8. Wang L., Mehta S., Brock M., and Gill S.E. (2017) Inhibition of Pulmonary Microvascular Endothelial Cell Apoptosis Promotes Recovery of Barrier Function Under Septic Conditions. Mediators Inflamm. 2017:3415380.
  9. Masciantonio M.G., Lee C.K.S., Arpino V., Mehta S., and Gill S.E. (2017) The Balance between Metalloproteinases and TIMPs: Critical Regulator of Microvascular Endothelial Cell Function in Health and Disease. Prog Mol Biol Transl Sci. 147:101-131.
  10. Arpino V., Mehta S., Wang L., Bird R., Rohan M., Pape C., and Gill S.E. (2016) Tissue inhibitor of metalloproteinases 3-dependent Microvascular Endothelial Cell Barrier Function is Disrupted Under Septic Conditions. Am J Physiol Heart Circ Physiol. 310 (11): H1455-67.
  11. Gill S.E., Nadler S.T., Li Q., Frevert C.W., Park P.W., Chen P., and Parks W.C. (2016) Matrilysin (MMP7) Shedding of Syndecan-1/Chemokine Complexes from Epithelium Functions as a Checkpoint of Neutrophil Activation. Am J Respir Cell Mol Biol. 55 (2): 243-251.
  12. Gill S.E., Yamashita C.M., and Veldhuizen R.A.W. (2016) Lung remodelling associated with the recovery from acute lung injury. Cell Tissue Res. 367(3): 495-509.
  13. Gill S.E., Rohan M., Pape C., and Mehta S. (2015) Role of pulmonary microvascular endothelial cell apoptosis in murine sepsis-induced lung injury in vivo. Respir Res. 16 (1): 109.
  14. Arpino V., Brock M., and Gill S.E. (2015) The role of TIMPs in extracellular matrix proteolysis. Matrix Biol. 44-46: 247-54.

Contact Information

London Health Sciences Centre, Victoria Hospital

Room A6-124

Phone: (519) 685-8500 x 55443