Dr. Constance Mackenzie, MD, MSc, FRCPC

Rank / Affiliations

  • Assistant Professor, Western University
  • Assistant Medical Director Ontario/Manitoba/Nunavut Poison Centre
  • Department of Clinical Pharmacology and Toxicology, The Hospital For Sick Children, Toronto, ON
  • POEM (Program of Experimental Medicine) member, Western University

 

Cross Appointments

  • Respirology, Western University, London, ON
  • Clinical Pharmacology and Toxicology, Western University, London, ON
  • Clinical Pharmacology and Toxicology, University of Toronto, Toronto, ON
  • The Hospital For Sick Children, Toronto, ON

 

Training

  • Undergraduate BSc (Hons), Western University
  • MSc, Trent University
  • MD, University of Ottawa
  • Internal Medicine, Western University (FRCPC 2010)
  • Respirology, Western University (FRCPC 2013)
  • Clinical Pharmacology & Toxicology, Western University (FRCPC 2013)

 

Clinical Interests

  • Occupational lung diseases
  • Asthma
  • Medical toxicology

 

Research interests

  • Pharmacogenetics of inhaled steroids in asthma
  • Cyclosporine as a novel treatment for amatoxin-containing mushroom poisoning 
  • Vaping-associated lung injury

 

Recent Publications

Landman ST, Dhaliwal I, Mackenzie CA, Martinu T, Steele A, Bosma KJ. Life-threatening bronchiolitis related to electronic cigarette use in a Canadian youth. CMAJ. 2019;191(48):E1321–E1331. doi:10.1503/cmaj.191402

Austin E, Myron HS, Summerbell RK, Mackenzie C. Acute renal injury cause by confirmed Psilocybe cubensis mushroom ingestion. Med Mycol Case Rep. 2018;23:55–57. doi:10.1016/j.mmcr.2018.12.007

Mackenzie CA. Fool Me Once…Fool Me Twice….The Rise of E-Cigarettes. Update on Respiratory Health, Research and Education, Ontario Respiratory Care Society, The Lung Association, Winter 2020 Issue 10

Ali J, Thompson M, Mackenzie CA. (2024).   Assessing the frequency and types of errors involved in the use of a modified intravenous N-acetylcysteine protocol for acetaminophen overdose. CJEM. https://doi.org/10.1007/s43678-023-00641-9
 
McIntosh MJ, Hofmann JJ, Kooner HK, Eddy RL, Parraga G and Mackenzie CA. (2024). 129Xe MRI and Oscillometry of Irritant-Induced Asthma After Bronchial Thermoplasty. Chest. Feb;165(2):e27-e31.
 
Jae J, Yilong L, Mackenzie CA. (2023). Posterior reversible encephalopathy syndrome following iatrogenic acetylcysteine overdose: a case report. Toxicology Communications, 7:1, DOI: 10.1080/24734306.2023.2292879
 
McIntosh MJ, Kooner HK, Eddy RL, Wilson A, Serajeddini H, Bhalla A, Licskai C, Mackenzie CA, Yamashita C, Parraga G. (2023). CT Mucus Score and 129Xe MRI Ventilation Defects After 2.5 Years' Anti-IL-5Rα in Eosinophilic Asthma. Chest. Jul;164(1):27-38.
 
Shrestha N, Mackenzie CA, Licskai C, Kim RB, Vliagoftis H, Cameron L. (2022). The CRTh2 Polymorphism rs533116 G>A associates with Asthma Severity in Older Females. Frontiers in Medicine, section, Pulmonary Medicine. 13;9:970495.
 
Mackenzie CA, Austin, E, Thompson, M, Tirona, RG. (2022). Cyclosporine as a novel treatment for amatoxin-containing mushroom poisoning: a case series. Toxicology Communications. 6(1): 23-27.
 
McIntosh MJ, Kooner HK, Eddy RL, Jeimy S, Licskai C, Mackenzie CA, Svenningsen S, Nair P, Yamashita C and Parraga G. (2022). Asthma control, Airway mucus and 129Xe MRI ventilation after a single Benralizumab dose. Chest. 2022 Sep;162(3):520-533.
 
Clemens K, Le B, Mackenzie CA, Vinegar M, Shariff SZ. (2021). Childhood food insecurity and asthma: a population-based cohort study of 27 746 children in Ontario, Canada. PLOS ONE. June 9, 2021: 1-15.
 
Kendzerska T, Leung RS, Boulos MI, McIsaac DI, Murray BJ, Bryson GL, Talarico R, Malhotra A, Gershon AS, Mackenzie CA, Povitz M. (2021). An Association between Positive Airway Pressure Device Manufacturer and Incident Cancer? A Secondary Data Analysis. American journal of respiratory and critical care medicine. 204(12): 1484-1488.

 

Contact Information

St. Joseph's Health Care

268 Grosvenor Street

Phone: (519) 646-6000 x66065