Timothy Regnault
Associate Professor
Obstetrics and Gynaecology (Primary Appointment)
PH.D. University of Western Sydney, Australia
B.Rur.Sci (Hons) University of New England, Australia
Office: Dental Science Building, Room 2021
The Susan Vitali-Lovell Laboratory for Studies in
Fetal Programming of Human Health Risks
p. 519.661.2111 x. 83528
f. 519.646.6213
e. tim.regnault@uwo.ca
See Publications by Dr. Regnault on PubMed
My research activities are focused around the in utero origins of adult metabolic disease. Through the use of cell based and animal/human model systems, and technologies such as PET/CT and MRI, we investigate, how stressors such as hypoxia, oxidative stress and infection and poor maternal diet during fetal life, impact placental, and fetal blood vessel, liver, adipose, kidney, heart and muscle development and function. These studies aim to address what reprogramming events these stressors initiate in the womb and what are the implications of these outcomes for the onset and severity of childhood and adult diseases, such as insulin resistance and associated non-communicable diseases including obesity, cardiovascular disease and hypertension. More importantly the research sets out to understand the degree of plasticity of these changes by investigating, if they are locked after being reprogrammed, or are there windows of opportunity for us to intervene and rescue some of these unfavorable in utero-induced changes.
Publications
Sarr O, Thompson JA, Zhao L, Lee TY, Regnault TR. Low birth weight male guinea pig offspring display increased visceral adiposity in early adulthood.PLoS One. 2014 Jun 13;9(6):e98433.
PMID: 24926663
Macdonald EM, Natale R, Regnault TR, Koval JJ, Campbell MK. Obstetric conditions and the placental weight ratio. Placenta. 2014 Aug;35(8):582-6. PMID: 24909371
Thompson JA, Piorkowska K, Gagnon R, Richardson BS, Regnault TR. Increased collagen deposition in the heart of chronically hypoxic ovine fetuses. J Dev Orig Health Dis. 2013 Dec;4(6):470-8. PMID: 24924226
Regnault TR, de Vrijer B, Galan HL, Wilkening RB, Battaglia FC, Meschia G. Umbilical uptakes and transplacental concentration ratios of amino acids in severe fetal growth restriction.Pediatr Res. 2013 May;73(5):602-11.PMID: 23407119
Kim-Fine S, Regnault TR, Lee JS, Gimbel SA, Greenspoon JA, Fairbairn J, Summers K, de Vrijer B. Male gender promotes an increased inflammatory response to lipopolysaccharide in umbilical vein blood.J Matern Fetal Neonatal Med. 2012 Nov;25(11):2470-4. PMID: 22506729
Thompson JA, Gros R, Richardson BS, Piorkowska K, Regnault TR. Central stiffening in adulthood linked to aberrant aortic remodeling under suboptimal intrauterine conditions.Am J Physiol Regul Integr Comp Physiol. 2011 Dec;301(6):R1731-7. PMID: 21900641
Regnault TR, Zhao L, Chiu JS, Gottheil SK, Foran A, Yee SP. Peroxisome Proliferator-Activated Receptor -β/δ, -γ Agonists and Resveratrol Modulate Hypoxia Induced Changes in Nuclear Receptor Activators of Muscle Oxidative Metabolism.PPAR Res. 2010;2010:129173. PMID: 21113404
