Faculty Research
Imaging of Pathogens and Immune Cells
High-resolution microscopy; Electron microscopy; Imaging in cells and in animals
This group uses a variety of state-of-the-art imaging techniques to understand cellular and molecular mechanisms underlying diseases, study the progression of infectious diseases, identify efficacious antimicrobial agents, develop diagnostic reagents to characterize hidden reservoirs of pathogens, and for the early and accurate detection of infections.
Faculty
Faculty Researcher | Research Area |
---|---|
Eric Arts | HIV pathogenesis, evolution and vaccine development |
Stephen Barr | Virus-host interactions of emerging viral pathogens |
Gregory Dekaban | Development of immunotherapies for cancer, infectious disease and neurotrauma |
Jimmy Dikeakos | We study the movement of proteins within HIV-1 infected and non-infected cells. |
David Heinrichs | Pathogenic mechanisms of Staphylococcus aureus (or MRSA) |
Bryan Heit | Macrophage function in health & disease |
Steven Kerfoot | B cell immune responses and their role in inflammatory disease |
John McCormick | Bacterial toxins of Streptococcus pyogenes and Staphylococcus aureus |
Ryan Troyer | We study molecular and cellular virology using multiple virus-host systems |
Bacteriology & Clinical Bacteriology
Microbiome; Antibiotic resistance; Bacterial ecosystems; Probiotics; Plant microbes
This group focuses on understanding the cellular and molecular mechanisms underlying bacteria-host interactions that drive normal and diseased states in plants and animals. Techniques used include bioinformatics, proteomics, genomics, molecular biology, structural biology, epigenetics, state-of-the-art imaging, animal infection models, and genetics of model organisms.
Faculty
Faculty Researcher | Research Area |
---|---|
Jeremy Burton | Microbiota associated with Urology |
Ana Cabrera | Head of the Molecular Microbiology Laboratory at LHSC |
Carole Creuzenet | Glycobiology, virulence factors and host interactions for gastro-intestinal bacterial pathogens |
Yohan Delport | Rapid methods of identifying bacterial pathogens from patients with suspected bacteremia |
David Heinrichs | Pathogenic mechanisms of Staphylococcus aureus (or MRSA) |
Aleksandra Leligdowicz | Immune regulation in early critical illness |
John McCormick | Bacterial toxins of Streptococcus pyogenes and Staphylococcus aureus |
Martin McGavin | Sensing and response of Staphylococcus aureus to chemical signals of innate immunity |
Gregor Reid | Probiotic applications to humans and other life-forms |
Immunology, Autoimmunity, Inflammation & Transplantation
Immune system responses to pathogens and diseases
This group focuses on a wide range of topics aimed at better understanding the immunological processes underlying human disease, organ failure and transplant organ preservation.
Faculty
Faculty Researcher | Research Area |
---|---|
Lillian Barra | Pathogenesis of rheumatoid arthritis and associated co-morbidities |
Ewa Cairns | Our laboratory is interested in rheumatic autoimmune diseases |
Lisa Cameron | T cell biology and chronic inflammatory disease |
Gregory Dekaban | Development of immunotherapies for cancer, infectious disease and neurotrauma |
Rodney DeKoter | Transcription factors, animal models, genetic mutations, leukemia, immune system diseases |
Lakshman Gunaratnum | Acute Kidney Injury and repair, Kidney transplantation, Tumour immunology |
Mansour Haeryfar | We investigate innate-like and adaptive T cell responses to cancer, viral pathogens and bacterial infections. |
Bryan Heit | Macrophage function in health & disease |
Chil-Yong Kang | Development of vaccines against human viral diseases |
Tony Jevnikar | Nephrology/Transplantation |
Steven Kerfoot | B cell immune responses and their role in inflammatory disease |
Sung Kim | Our research program focuses on the signaling and epigenetic mechanisms of innate immune cells in responding to various microbes, tissue injury and cancers |
James Koropatnick | Development of small molecule, antisense, and antibody-based drugs to treat cancer |
Aleksandra Leligdowicz | Immune regulation in early critical illness |
John McCormick | Bacterial toxins of Streptococcus pyogenes and Staphylococcus aureus |
Jessica Prodger | Developing Novels Strategies for HIV Prevention and Cure in Africa |
Alp Sener | Novel transplant organ preservation strategies using temperature modulation and gasotransmitter therapy with the ultimate goal of improving long term graft function and survival |
Bhagirath Singh | Regulation of Type 1 diabetes by autoantigens, regulatory T cells and microbes |
Cancer & Tumour Biology
Cancer immunology; Cancer treatment; DNA tumour viruses; Cancer gene regulation
This groups investigates the molecular mechanisms of cancer and how the immune system responds to it. This research includes cancer gene regulation, animal models, innate and adaptive T cell responses, and DNA tumour viruses that cause cancer. This research exploits such techniques as bioinformatics, genomics, proteomics, cellular and molecular biology, and animal models.
Faculty
Faculty Researcher | Research Area |
---|---|
Rodney DeKoter | Transcription factors, animal models, genetic mutations, leukemia, immune system diseases |
Lakshman Gunaratnum | Acute Kidney Injury and repair, Kidney transplantation, Tumour immunology |
Mansour Haeryfar | We investigate innate-like and adaptive T cell responses to cancer, viral pathogens and bacterial infections. |
James Koropatnick | Development of small molecule, antisense, and antibody-based drugs to treat cancer |
Joe Mymryk | DNA tumor viruses and associated human cancers |
Virology & Viral Pathogenesis
Viruses; Animal models of disease
This group focuses on understanding the cellular and molecular mechanisms underlying virus-host interactions that drive normal and diseased states. Techniques used include bioinformatics, proteomics, genomics, molecular biology, structural biology, epigenetics, state-of-the-art imaging, animal infection models, and genetics of model organisms.
Faculty
Faculty Researcher | Research Area |
---|---|
Eric Arts | HIV pathogenesis, evolution and vaccine development |
Stephen Barr | Virus-host interactions of emerging viral pathogens |
Gregory Dekaban | Development of immunotherapies for cancer, infectious disease and neurotrauma |
Jimmy Dikeakos | We study the movement of proteins within HIV-1 infected and non-infected cells. |
Mansour Haeryfar | We investigate innate-like and adaptive T cell responses to cancer, viral pathogens and bacterial infections. |
Chil-Yong Kang | Development of vaccines against human viral diseases |
Joe Mymryk | DNA tumor viruses and associated human cancers |
Jessica Prodger | Developing Novels Strategies for HIV Prevention and Cure in Africa |
Ryan Troyer | We study molecular and cellular virology using multiple virus-host systems |
Bioinformatics, Genomics & Genetics
Evolution; Epidemiology; Genomics
This group uses a variety of bioinformatic approaches to better understand host-pathogen interactions, mechanisms of disease, evolution of pathogens, & microbiota compositions.
Faculty
Faculty Researcher | Research Area |
---|---|
Eric Arts | HIV pathogenesis, evolution and vaccine development |
Stephen Barr | Virus-host interactions of emerging viral pathogens |
Jeremy Burton | Microbiota associated with Urology |
Lisa Cameron | T cell biology and chronic inflammatory disease |
Rodney DeKoter | Transcription factors, animal models, genetic mutations, leukemia, immune system diseases |
Sung Kim | Our research program focuses on the signaling and epigenetic mechanisms of innate immune cells in responding to various microbes, tissue injury and cancers |
Martin McGavin | Sensing and response of Staphylococcus aureus to chemical signals of innate immunity |
Joe Mymryk | DNA tumor viruses and associated human cancers |
Art Poon | Bioinformatics, phylogenetics and the molecular epidemiology of human viruses |
Jessica Prodger | Developing Novels Strategies for HIV Prevention and Cure in Africa |
Gregor Reid | Probiotic applications to humans and other life-forms |
Ryan Troyer | We study molecular and cellular virology using multiple virus-host systems |
Vaccine & Drug Discovery
Vaccine development; Animal models of disease and protection; Drug development and testing
This group uses cellular and molecular approaches to develop and test novel vaccines and therapeutic drugs to combat human diseases.
Faculty
Faculty Researcher | Research Area |
---|---|
Eric Arts | HIV pathogenesis, evolution and vaccine development |
Stephen Barr | Virus-host interactions of emerging viral pathogens |
Gregory Dekaban | Development of immunotherapies for cancer, infectious disease and neurotrauma |
Jimmy Dikeakos | We study the movement of proteins within HIV-1 infected and non-infected cells. |
Chil-Yong Kang | Development of vaccines against human viral diseases |
James Koropatnick | Development of small molecule, antisense, and antibody-based drugs to treat cancer |
Gregor Reid | Probiotic applications to humans and other life-forms |
Ryan Troyer | We study molecular and cellular virology using multiple virus-host systems |