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• Rocio Sedano

Rocio Sedano

Dr. Sedano is an Assistant Professor of Medicine in the Division of Gastroenterology with a cross-appointment in the Department of Biostatistics and Epidemiology at Western University. She is a Lawson Scientist and a Scientist in the Program of Experimental Medicine. She completed her MD at Universidad de Los Andes, Chile, Internal Medicine residency at Universidad de Valparaiso, Chile, and Gastroenterology fellowship at Universidad de Chile. She subsequently completed an Advanced Clinical and Research fellowship in Inflammatory Bowel Disease, followed by a fellowship in Motility and Neurogastroenterology at Western University. She is currently completing an MSc in Clinical Trials at the University of London and the London School of Hygiene and Tropical Medicine, UK.

Her clinical practice focuses on the management of Inflammatory Bowel Disease (IBD) and GI Motility Disorders.

Selected Publications

Jairath V, Zou G, Wang Z, Adsul S, Colombel JF, D'Haens GR, Freire M, Moran GW, Peyrin-Biroulet L, Sandborn WJ, Sebastian S, Travis S, Vermeire S, Radulescu G, Sigler J, Hanžel J, Ma C, Sedano R, McFarlane SC, Arya N, Beaton M, Bossuyt P, Danese S, Green D, Harlan W 3rd, Horynski M, Klopocka M, Petroniene R, Silverberg MS, Wolanski L, Feagan BG. Determining the optimal treatment target in patients with ulcerative colitis: rationale, design, protocol and interim analysis for the randomised controlled VERDICT trial. BMJ Open Gastroenterol. 2024 Feb 8;11(1):e001218.

Alphonsus L, De Silva TA, Ma C, MacDonald JK, Hanzel J, Beaton M, Bessissow T, Kayal M, Sedano R, Singh S, Jairath V. Systematic review and meta-analysis of randomised controlled trials: Medical therapies for the treatment and prevention of pouchitis. Aliment Pharmacol Ther. 2023 Aug;58(3):268-282.

Ma C, Panaccione R, Xiao Y, Khandelwal Y, Murthy SK, Wong ECL, Narula N, Tsai C, Peerani F, Reise-Filteau M, Bressler B, Starkey SY, Loomes D, Sedano R, Jairath V, Bessissow T. REMIT-UC: Real World Effectiveness and Safety of Tofacitinib for Moderate-to-Severely Active Ulcerative Colitis. Am J Gastroenterol. 2023 May 1;118(5):861-871.

Sedano R, Cabrera D, Jiménez A, Ma C, Jairath V, Arrese M, Arab JP. Immunotherapy for Cancer: Common Gastrointestinal, Liver, and Pancreatic Side Effects and Their Management. Am J Gastroenterol. 2022 Dec 1;117(12):1917-1932.

Maratt JK, Siegel CA, Barkun AN, Bouhnik Y, Bressler B, Calderwood AH, East JE, Fischer M, Grossmann J, Korzenik JR, Menees SB, Panes J, Rex DK, Sey MSL, Allio MK, Baker KA, Guizzetti L, Remillard J, Sedano R, Feagan BG, Ma C, Jairath V. An Expert Consensus to Standardize Assessment of Bowel Cleansing for Clinical Trials of Bowel Preparations for Crohn's Disease. Dig Dis Sci. 2023 May;68(5):1718-1727.

Sharma T, Ma C, Sedano R, Hanzel J, McDonald C, Hogan M, Kochhar GS, Narula N, Peyrin-Biroulet L, Danese S, MacDonald JK, Jairath V. Placebo response rates in randomized controlled trials for perianal Crohn's disease: A systematic review and meta-analysis. J Crohns Colitis. 2023 Apr 19;17(4):644-658.

De Silva TA, Alphonsus L, Ma C, Hogan M, Sedano R, Narula N, Danese S, Peyrin-Biroulet L, MacDonald JK, Singh S, Jairath V. Placebo rates in randomized controlled trials of proctitis therapy: A systematic review and meta-analysis. J Crohns Colitis. 2023 Jan 27;17(1):123-136.

Sedano R, Guizzetti L, McDonald C, Beaton M, Chande N, Gregor J, Sey M, Wilson A, Jairath V. Clinical, Endoscopic, and Radiological Effectiveness of Ustekinumab in Bio-naïve Versus Bio-experienced Patients With Crohn's Disease: Real-world Experience From a Large Canadian Center. Inflamm Bowel Dis. 2023 Jun 1;29(6):866-874.

Sedano R, Hogan M, Zou G, Narula N, Singh S, Ma C, Feagan BG, Jairath V. Comparison of the Relative Sensitivity of Clinical, Endoscopic, and Histologic Remission for Detection of Treatment Efficacy in Ulcerative Colitis Trials. Inflamm Bowel Dis. 2023 Feb 1;29(2):324-327.

Sedano R, Ma C, Jairath V, Feagan BG. Janus Kinase Inhibitors for the Management of Patients With Inflammatory Bowel Disease. Gastroenterol Hepatol (N Y). 2022 Jan;18(1):14-27.

Xiao Y, Benoit N, Sedano R, Jairath V, Narula N, McCurdy JD, Rosenfeld G, Afif W, Lakatos PL, Bessissow T. Effectiveness of Tofacitinib for Hospitalized Patients with Acute Severe Ulcerative Colitis: Case Series. Dig Dis Sci. 2022 Nov;67(11):5213-5219.

Hanzel J, Ma C, Jairath V; IBD Trial Design Group, Sedano R, Shackelton LM, D'Haens GR, Sandborn WJ, Feagan BG. Design of clinical trials for mild-to-moderate Crohn's disease. Gastroenterology. 2022 Feb 28:S0016-5085(22)00202-5.

Hanžel J, Sedano R, Jeyarajah J, Zou G, McFarlane SC, Ma C, Jairath V. Similar Clinical Improvement Rates Among Biologic Drug Classes in Crohn's Disease: Systematic Review and Meta-Regression. Inflamm Bowel Dis. 2022 Sep 1;28(9):1462-1464.

Sedano R, Hogan M, McDonald C, Aswani-Omprakash T, Ma C, Jairath V. Underrepresentation of Minorities and Lack of Race Reporting in Ulcerative Colitis Drug Development Clinical Trials. Inflamm Bowel Dis. 2022 Aug 1;28(8):1293-1295.

Sedano R, Jairath V, Ma C; IBD Trial Design Group. Design of Clinical Trials for Mild to Moderate Ulcerative Colitis. Gastroenterology. 2022 Apr;162(4):1005-1018

Shen B, Kochhar GS, Rubin DT, Kane SV, Navaneethan U, Bernstein CN, Cross RK, Sugita A, Schairer J, Kiran RP, Fleshner P, McCormick JT, D'Hoore A, Shah SA, Farraye FA, Kariv R, Liu X, Rosh J, Chang S, Scherl E, Schwartz DA, Kotze PG, Bruining DH, Philpott J, Abraham B, Segal J, Sedano R, Kayal M, Bentley- Hibbert S, Tarabar D, El-Hachem S, Sehgal P, Picoraro JA, Vermeire S, Sandborn WJ, Silverberg MS, Pardi DS. Treatment of pouchitis, Crohn's disease, cuffitis, and other inflammatory disorders of the pouch: consensus guidelines from the International Ileal Pouch Consortium. Lancet Gastroenterol Hepatol. 2022 Jan;7(1):69-95.

Almradi A, Sedano R, Hogan M, Zou GY, MacDonald J, Parker C, Hanzel J, Crowley E, Singh S, Feagan B, Ma C, Jairath V. Clinical, endoscopic and safety placebo rates in induction and maintenance trials of Crohn's disease: Meta-analysis of Randomised controlled trials. J Crohns Colitis. 2022 Jun 24;16(5):717-736.

Sedano R, Hogan M, McDonald C, Aswani-Omprakash T, Ma C, Jairath V. Underrepresentation of minorities and under-reporting of race and ethnicity in Crohn's Disease Clinical Trials Gastroenterology. 2022 Jan;162(1):338-340.e2.

Singh S, Murad M, Fumery M, Sedano R, Jairath V, Panaccione R, Sandborn W, Ma C. Comparative Efficacy and Safety of Biologic Therapies for Moderate-to-Severe Crohn’s Disease: A Systematic Review and Network Meta-Analysis. Lancet Gastroenterol Hepatol. 2021 Dec;6(12):1002-1014.

Ble A, Renzulli C, Cenci F, Grimaldi M, Barone M, Sedano R, Chang J, Nguyen TM, Hogan M, Zou GY, MacDonald JK, Ma C, Sandborn WJ, Feagan BG, Merlo Pich E, Jairath V. The relationship between endoscopic and clinical recurrence in postoperative Crohn's disease: a systematic review and meta- analysis. J Crohns Colitis. 2022 Mar 14;16(3):490-499.

Sedano R, Hogan M, Nguyen TM, Chang J, Zou GY, Macdonald JK, Vande Casteele N, Hanzel J, Crowley E, Battat R, Dulai PS, Singh S, D'Haens G, Sandborn W, Feagan BG, Ma C, Jairath V. Systematic review and Meta-analysis: Clinical, Endoscopic, Histologic and Safety Placebo Rates in Induction and Maintenance trials of Ulcerative Colitis. J Crohns Colitis. 2022 Feb 23;16(2):224-243.

Shen B, Kochhar G, Kariv R, Liu X, Navaneethan U, Rubin DT, Cross RK, Sugita A, D’Hoore A, Schairer J, Farraye FA, Kiran RP, Fleshner P, Rosh J, Shah SA, Chang S, Scherl E, Pardi DS, Schwartz DA, Kotze PG, Bruining DH, Kane SV, Philpott J, Abraham B, Segal J, Sedano R, Kayal M, Bentley-Hibbert S, Tarabar D, El- Hachem S, Sehgal P, McCormick JT, Picoraro JA, Silverberg MS, Bernstein CN, Sandborn WJ, Vermeire S. Diagnosis and classification of ileal pouch disorders: consensus guidelines from the International Ileal Pouch Consortium. Lancet Gastroenterol Hepatol. 2021 Oct;6(10):826-849.

Sedano R, Nguyen TM, Almradi A, Rieder F, Parker CE, Shackelton LM, D’Haens G, Sandborn WJ, Feagan BG, Ma C, Jairath V. Disease Activity Indices for Pouchitis: A Systematic Review. Inflamm Bowel Dis. 2022 Mar 30;28(4):622-638.

Hussameddin A, Sedano R, Ramsewak D, Driman D, Jairath V. Vedolizumab-Induced Endoscopic and Histologic Improvement in Gastric Menetrier's Disease in a Patient with Ulcerative Colitis. Inflamm Bowel Dis. 2021 Oct 20;27(11):e132-e133.

Jairath V, Guizzetti L, Baker KA, Williamson LA, Sedano R, Thompson H, Ma C. Impact of COVID-19 on Inflammatory Bowel Disease Clinical Trial Recruitment: A Global Survey of Principal Investigators. Inflamm Bowel Dis. 2021 Jul 27;27(8):e98.

Sedano R, Ma C, Jairath V. Editorial: standardising inclusion and outcome criteria for pouchitis-a fragile consensus perhaps but a first step in the right direction. Authors' reply. Aliment Pharmacol Ther. 2021 May;53(10):1149-1150.

Sedano R, Ma C, Pai RK, D' Haens G, Guizzetti L, Shackelton LM, Remillard J, Gionchetti P, Gordon IO, Holubar S, Kayal M, Lauwers GY, Pai RK, Pardi DS, Samaan MA, Schaeffer DF, Shen B, Silverberg MS, Feagan BG, Sandborn WJ, Jairath V. An expert consensus to standardise clinical, endoscopic and histologic items and inclusion and outcome criteria for evaluation of pouchitis disease activity in clinical trials. Aliment Pharmacol Ther. 2021 May;53(10):1108-1117.

Ma C, Sedano R, Almradi A, Casteele NV, Parker CE, Guizzetti L, Schaeffer DF, Riddell RH, Pai RK, Battat R, Sands BE, Rosty C, Dubinsky MC, Rieder F, Harpaz N, Abreu MT, Bryant RV, Lauwers GY, Kirsch R, Valasek MA, Crowley E, Sandborn WJ, Feagan BG, Pai RK, Jairath V. An International Consensus to Standardize Integration of Histopathology in Ulcerative Colitis Clinical Trials. Gastroenterology. 2021 Jun;160(7):2291-2302.

Sedano R, Jairath V. Tofacitinib for the Treatment of Three Immune-mediated Conditions in One Patient: Ulcerative Colitis, Pyoderma Gangrenosum, and Alopecia Areata. Inflamm Bowel Dis. 2021 Apr 15;27(5):e65.

Sedano R, Jairath V. High-Dose Rescue Tofacitinib Prevented Inpatient Colectomy in Acute Severe Ulcerative Colitis Refractory to Anti-TNF. Inflamm Bowel Dis. 2021 Apr 15;27(5):e59-e60.

Sedano R, Dhaliwal I, Ramsewak D, Jairath V. Drug-induced Lupus Associated With Vedolizumab in a Patient with Crohn's Disease. Inflamm Bowel Dis. 2021 Mar 15;27(4):e47-e48.

Sedano R, Jairath V. Tofacitinib Induced Long-term Clinical, Endoscopic, and Histological Remission as a 6th Line Agent in Medically Refractory Ulcerative Colitis. Inflamm Bowel Dis. 2021 Feb 16;27(3):e35- e36.

Almradi A, Hanzel J, Sedano R, Parker C, Feagan B, Ma C, Jairath V. Clinical trials of IL-12/IL-23 inhibitors in Inflammatory Bowel Disease. BioDrugs. 2020 Dec;34(6):713-721.

Nunez P, Sedano R, Quera R, Carrasco G, O´Brien A, Brahm J. Autoimmune sequential overlap syndrome (autoimmune hepatitis/primary sclerosing cholangitis) and inflammatory bowel disease: three clinical cases. Rev Esp Enferm Dig 2020.

Sedano R, Guizzetti L, McDonald C, Jairath V. Intravenous Ustekinumab Reinduction Is Effective in Prior Biologic Failure Crohn's Disease Patients Already on Every-4-Week Dosing. Clin Gastroenterol Hepatol. 2021 Jul;19(7):1497-1498.e1.

Sedano R, Almradi A, Ma C, Jairath V, Feagan B. Novel Therapeutics for the Treatment of IBD: Current Status and Future Directions. Curr Treat Options Gastro 2020.

Klein M, Nunez P, Bay C, Pizarro C, Sedano R, Quera R. Liver Disorders in Inflammatory Bowel Disease. EMJ Hepatol. 2020;8[1]:26-32

Quera R, Sedano R, Nunez P. Is fecal microbiota transplantation currently a therapeutic option in patients with irritable bowel syndrome? Rev Med Chile 2020; 148: 713-714

Perez de Arce E, Sedano R, Quera R. Biomarkers in Inflammatory Bowel Disease: Do you know how to use them? Rev Med Chile 2020; 148: 362-370.

Sedano R, Nunez P, Quera R. Diagnostic and management approach to pouchitis in inflammatory bowel disease. Arq Gastroenterol. 2020;57(1):100-106.

Sedano R, Quera R, Simian D, Yarur A. An approach to acute severe ulcerative colitis. Expert Rev Gastroenterol Hepatol. 2019 Oct;13(10):943-955.

Sedano R, Quera R, Espinoza R. Letter to the Editor: Clostridioides difficile infection: Should we change our approach in diagnosis and treatment. Rev Chilena Infectol 2019; 36 (5): 675-676

Quera R, Sedano R, Espinoza R, Rivera D. Fecal microbiota transplant in octogenarian patients with recurrent infection by Clostridioides difficile: An experience from two clinical cases. Rev Chilena Infectol 2019; 36 (4): 536-540.

Sedano R, Castro L, Venegas M., Miranda J., Hurtado C., Poniachik J., Brahm J. Liver Transplantation in acute liver failure due to Hepatitis B. Two clinical cases. Ann Hepatol. 2021 Mar-Apr;21:100107.

Sedano R, Quera R, Ibanez P, Figueroa C, Flores L. Aminosalicylates, thiopurines and methotrexate in inflammatory bowel disease: is it possible to discontinue the treatment? Gastroenterol Hepatol. 2019 May;42(5):339-347.

Sedano R, Quera R, Lubascher J, Pizarro G, Simian D. Evaluation of de-escalation of anti-TNF-α therapy in Inflammatory bowel disease. Gastroenterol Hepatol, 2019 Feb;42(2):133-140.