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Aze Wilson

Dr. Aze Wilson is a clinical gastroenterologist and an Assistant Professor of Medicine at Western University. She joined the Division of Gastroenterology in 2016 as a Clinician-Researcher with a focus on translational research in inflammatory bowel disease. She also has a cross-appointment with the Division of Clinical Pharmacology and the Department of Physiology & Pharmacology.  Dr. Wilson began her scientific training at Queen's University, where she completed an honours BSc. in Life Sciences.  She completed her medical education at Western University, becoming accredited in both Internal Medicine and Gastroenterology.  She completed the Royal College-certified Clinician-Investigator Program in 2016 in addition to completing her PhD in Physiology and Pharmacology. Her clinical interests include inflammatory bowel disease and other luminal diseases. Her research interests include drug metabolism and drug response in inflammatory bowel disease, with a particular focus on genetic markers of drug response.

Selected Publications

Wilson A, Wang Q, Ponich T, Gregor JC, Chande N, Yan B, Sey M, Beaton M, Kim RB. Pre-treatment HLADQA1-HLADRB1 testing for the prevention of azathioprine-induced pancreatitis in inflammatory bowel disease: a prospective cohort study. Clinical and Translational Gastroenterology, 2020 Nov 1, Principal Author [submitted].

Wilson A, Choi B, Sey M, Ponich T, Beaton M, Kim RB.  High infliximab trough concentrations are associated with sustained histologic remission in inflammatory bowel disease.  BMC Gastroenterology, 2020 Nov 1, Principal Author [submitted].

Imasogie N, Rose RV, Wilson A. High Quantities: Evaluating the Effect of Cannabis Use on Propofol Anesthesia during Endoscopy.  PLOS One, 2020 Aug 1, Senior Author [submitted].

Mikail M, Wilson A. Serum tumor necrosis factor-α antagonist concentrations in patients with pyoderma gangrenosum associated with inflammatory bowel disease: a case series. BMC Gastroenterology. 2020 Dec 11, Senior Author [submitted].

Townsend C, Khanna R, Wilson A.  A More Severe Non-melanoma Skin Cancer Phenotype is Seen in Patients with Inflammatory Bowel Disease on Tumor Necrosis Factor-α Antagonists. Digestives Diseases and Sciences, 2020 December, Senior Author [accepted, in press]

Mikail M, Wilson A. Infliximab exposure in large, multifocal, abdominal pyoderma gangrenosum associated with ulcerative colitis: a case report. Sage Open Medical Case Reports, 2020 Oct 23;8:2050313X20964113. doi: 10.1177/2050313X20964113.  Senior Author

Wilson A, Beaton MD, Brahmania M. Letter to the editor: non-alcoholic fatty liver disease - one size may not fit all. Hepatology. 2020 Sep 23. doi: 10.1002/hep.31564. Principal Author

Wilson A, Wang Q, Almousa AA, Jansen LE, Choi Y, Schwarz UI, Kim RB. Genetic variation in the Farnesoid X-Receptor Predicts Crohn’s Disease Severity in Female Patients. Scientific Reports, 10, 11725 (2020). doi.org/10.1038/s41598-020-68686-9.  Principal Author

Al Draiweesh S, Ma C, Alkhattabi M, McDonald C, Nguyen TM, Beaton M, Chande N, Colquhoun P, Feagan BG, Gregor JC, Khanna R, Marotta P, Ponich T, Quan D, Qumosani K, Sandhu A, Sey M, Skaro A, Teriaky A, Wilson A, Yan B, Brahmania M, Jairath V. Safety of Combination Biologic and Antirejection Therapy Post-Liver Transplantation in Patients With Inflammatory Bowel Disease. Inflamm Bowel Dis, 2020 Jun; 26(6):949-59, Coauthor, DOI: 10.1093/ibd/izz244.

Wilson A, Peel C, Wang Q, Pananos AD, Kim RB. HLADQA1*05 genotype predicts anti-drug antibody formation and loss of response during infliximab therapy for inflammatory bowel disease. Aliment Pharmacol Ther, 2020 Feb; 51(3):356-363, Principal Author, DOI: 10.1111/apt.15563.

Wilson A, Almousa A, Teft WA, Kim RB. Attenuation of bile acid-mediated FXR and PXR activation in patients with Crohn’s disease. Sci Rep, 2020 Feb 5; 10 (1): 1866, Principal Author, DOI: 10.1038/s41598-020-58644-w.

Wilson A, Urquhart BL, Ponich T, Chande N, Gregor JC, Beaton M, Kim RB. Crohn’s Disease Is Associated with Decreased CYP3A4 and P-Glycoprotein Protein Expression. Mol Pharm, 2019 Sep 3; 16 (9): 4059-4064, Principal Author, DOI: 10.1021/acs.molpharmaceut.9b00459.

Zhu CN, Friedland J, Yan B, Wilson A, Gregor J, Jairath V, Sey M. Presence of Melena in Obscure Gastrointestinal Bleeding Predicts Bleeding in the Proximal Small Intestine. Dig Dis Sci, 2018 May 1; 63 (5): 1280-1285, Coauthor, DOI: 10.1007/s10620-018-5003-x.

Wilson A, Jansen LE, Rose RV, Gregor JC, Ponich T, Chande N, Khanna R, Yan B, Jairath V, Khanna N, Sey M, Beaton M, McIntosh K, Teft WA, Kim RB. HLA-DQA1-HLA-DRB1 polymorphism is a major predictor of azathioprine-induced pancreatitis in patients with inflammatory bowel disease. Aliment Pharmacol Ther, 2018 Mar 1; 47 (5): 615-620, Principal Author, DOI: 10.1111/apt.14483.

Wilson A, Tirona RG, Kim RB. CYP3A4 Activity is Markedly Lower in Patients with Crohn’s Disease. Inflamm Bowel Dis, 2017 Mar 15, Principal Author, DOI: 10.1097/MIB.0000000000001062.

Teft WA, Morse BL, Leake BF, Wilson A, Mansell SE, Hegele RA, Ho RH, Kim RB. Identification and Characterization of Trimethylamine-N-oxide Uptake and Efflux Transporters. Mol Pharm, 2017 Jan 3; 14 (1): 310-318, Co-Author, DOI: 10.1021/acs.molpharmaceut.6b00937.

McLean C, Wilson A, Kim RB. Impact of Transporter Polymorphisms on Drug Development: Is It Clinically Significant? J Clin Pharmacol, 2016 Jul 1; 56 Suppl 7: S40-58, Coauthor, DOI: 10.1002/jcph.691.

Wilson A, McLean C, Kim RB. Trimethylamine-N-oxide: a link between the gut microbiome, bile acid metabolism, and atherosclerosis. Curr Opin Lipidol, 2016 Apr 1; 27 (2): 148-54, Principal Author, DOI: 10.1097/MOL.0000000000000274.

Wilson A, Teft WA, Morse BL, Choi YH, Woolsey S, DeGorter MK, Hegele RA, Tirona RG, Kim RB. Trimethylamine-N-oxide: A Novel Biomarker for the Identification of Inflammatory Bowel Disease. Dig Dis Sci, 2015 Dec 1; 60 (12): 3620-30, Principal Author, DOI: 10.1007/s10620-015-3797-3.

Wilson A, Kim RB. OATP transporters: Potential targets for enhancing organ and tissue specific drug delivery. Journal of Pharmacology and Clinical Toxicology, 2014 Nov; 2 (3): 1037-47, Principal Author

Wilson A, Patel V, Chande N, Ponich T, Urquhart B, Asher L, Choi Y, Tirona R, Kim RB, Gregor JC. Pharmacokinetic profiles for oral and subcutaneous methotrexate in patients with Crohn’s disease. Aliment Pharmacol Ther, 2013 Feb 1; 37 (3): 340-5, Principal Author, DOI: 10.1111/apt.12161.