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Michael Sey

Dr. Michael Sey is a gastroenterologist specializing in therapeutic endoscopy at the London Health Sciences Centre, an Associate Professor of Medicine at Western University, and a Scientist in the Lawson Health Research Institute. He completed his MD at the University of Toronto and his Internal Medicine and Gastroenterology residencies at Western University. Dr. Sey trained in Advanced Endoscopy at Indiana University Medical Centre, Clinical Trials development at Harvard Medical School, and completed a Master of Public Health at Harvard University. Currently, he is the Program Director for the Advanced Luminal Endoscopy Fellowship and the Regional Endoscopy Lead for Cancer Care Ontario. His clinical interests include double balloon enteroscopy, capsule endoscopy, endoscopic ultrasound, and endoscopic mucosal resection/submucosal dissection. His research focuses on gastrointestinal bleeding, advanced endoscopy, and quality in endoscopy.

Selected Publications

Sey M, Hsia Cy, Jairath V. Thalidomide for bleeding from small-intestinal angiodysplasia. N Engl J Med 2024;390:479-80.

Liu E, McDonald C, Son S, Hawel J, Hussain N, Khanna N, Yan B, Jairath V, Sey M. Extended delay in endoscopic mucosal resection is not associated with adverse outcomes: Findings from the COVID-19 pandemic. Endosc Int Open. 2023 May 9;11(5):E474-E479. doi: 10.1055/a-2048-1433. PMID: 37180309; PMCID: PMC10169224.

Arora A, McDonald C, Guizzetti L, Iansavichene A, Brahmania M, Khanna N, Wilson A, Jairath V, Sey M. Endoscopy Unit Level Interventions to Improve Adenoma Detection Rate: A Systematic Review and Meta-Analysis. Clin Gastroenterol Hepatol. 2023 Dec;21(13):3238-3257. doi: 10.1016/j.cgh.2023.03.049. Epub 2023 Apr 18. PMID: 37080261.

Tse C, Barkun A, Martel M, Nugent Z, Epstein I, Sey M, Richard S, von Renteln D, Singh H. Sleep Disturbances, Bowel Movement Kinetics, and Travel Interruption With Bowel Preparation: A Bowel CLEANsing National Initiative Substudy. Am J Gastroenterol. 2023 Jan 1;118(1):87-94. doi: 10.14309/ajg.0000000000002026. Epub 2022 Sep 21. PMID: 36148830.

Sedano R, Guizzetti L, McDonald C, Beaton M, Chande N, Gregor J, Sey M, Wilson A, Jairath V. Clinical, Endoscopic, and Radiological Effectiveness of Ustekinumab in Bio-naïve Versus Bio-experienced Patients With Crohn's Disease: Real-world Experience From a Large Canadian Center. Inflamm Bowel Dis. 2023 Jun 1;29(6):866-874. doi: 10.1093/ibd/izac149. PMID: 35851799

Choi B, Sey M, Ponich T, Beaton M, Kim R, Wilson A. Decreased Infliximab Concentrations in Patients With Inflammatory Bowel Disease Who Carry a Variable Number Tandem Repeat Polymorphism in the Neonatal Fc Receptor or Variant HLADQA1*05G>A Genotype. Inflamm Bowel Dis. 2023 Mar 1;29(3):437-443. doi: 10.1093/ibd/izac188. PMID: 36112504.

Maratt JK, Siegel CA, Barkun AN, Bouhnik Y, Bressler B, Calderwood AH, East JE, Fischer M, Grossmann J, Korzenik JR, Menees SB, Panes J, Rex DK, Sey MSL, Allio MK, Baker KA, Guizzetti L, Remillard J, Sedano R, Feagan BG, Ma C, Jairath V. An Expert Consensus to Standardize Assessment of Bowel Cleansing for Clinical Trials of Bowel Preparations for Crohn's Disease. Dig Dis Sci. 2023 May;68(5):1718-1727. doi: 10.1007/s10620-022-07775-3. Epub 2022 Nov 27. PMID: 36436154.

Hanzel J, Sey M, Ma C, Zou G, East JE, Siegel CA, Mosli M, Reinisch W, McDonald JWD, Silverberg MS, Van Viegen T, Shackelton LM, Clayton LB, Enns R, Epstein I, Hilsden RJ, Hookey L, Moffatt DC, Ng Kwet Shing R, Telford JJ, von Renteln D, Feagan BG, Barkun A, Jairath V. Existing Bowel Preparation Quality Scales Are Reliable in the Setting of Centralized Endoscopy Reading. Dig Dis Sci. 2023 Apr;68(4):1195-1207. doi: 10.1007/s10620-022-07729-9. Epub 2022 Oct 20. PMID: 36266592.

Sey M, Cocco S, McDonald C, Hindi Z, Rahman H, Chakraborty D, French K, Alsager M, Siddiqi O, Blier MA, Markandey B, Al Obaid S, Wong A, Siebring V, Brahmania M, Gregor J, Khanna N, Ott M, Qumosani K, Wilson A, Guizzetti L, Yan B, Jairath V. Association of Trainee Participation in Colonoscopy Procedures With Quality Metrics. JAMA Network Open. 2022;5(8):e2229538.

Almaghrabi M, Gandhi M, Guizzetti L, Iansavichene A, Yan B, Wilson A, Oakland K, Jairath V, Sey M. Comparison of Risk Scores for Lower Gastrointestinal Bleeding: A Systematic Review and Meta-analysis. JAMA Network Open. 2022;5:e2214253.

Sey M. Artificial Intelligence and the Promise of Expediting and Standardizing the Reviewing and Reporting of Capsule Endoscopy Videos. JAMA Network Open. 2022;5:e2222006.

Guo A, Ross C, Chande N, Gregor J, Ponich T, Khanna R, Sey M, Beaton M, Yan B, Kim RB, Wilson A. High oncostatin M predicts lack of clinical remission for patients with inflammatory bowel disease on tumor necrosis factor α antagonists. Scientific Report. 2022;12:1185.

Barkun A, Bardou M, Martel M, Epstein I, Halle P, Hilsden R, James PD, Rostom A, Sey M, Singh H, Sultanian R, Telford J, Von Renteln D. The Bowel CLEANsing National Initiative: High-Volume vs Low-Volume Split-Dose PEG Preparations – A randomized controlled trial. Clinical Gastroenterology Hepatology. 2022;20:e1469-77.

Sey M, von Renteln D, Sultanian R, McDonald C, Martel M, Bouin M, Chande N, Sandhu A, Yan B, Barkun AN. A multi-centre randomized controlled trial to compare two bowel cleansing regimens after a colonoscopy with inadequate bowel preparation. Clinical Gastroenterology and Hepatology. 2021;20:e1283-91.

Yan B, Sey M, Belletrutti P, Brahm G, Guizzetti L, Jairath V. Reliability of the Endoscopic Ultrasound Ulcerative Colitis (EUS-UC) Score for the assessment of Inflammation In patients with Ulcerative Colitis. Endoscopy International Open. 2021;9:E1116-22.

Aziz S, Sey M, Marotta P, Driman D, Parfitt J, Teriaky A, Brahmania M, Skaro A, Qumosani K. Recurrent hepatocellular carcinoma after liver transplantation: Validation of a pathological risk score on explanted livers to predict recurrence. Transplant Proceedings. 2021;53:1975-79.

Alotaibi A, Almaghrabi M, Brahmania M, Ahmed O, Rodrigues D, Iansavichene A, Puka K, Sey M, Patel K. Spontaneous bacterial peritonitis among asymptomatic cirrhosis patients undergoing outpatient paracentesis: a systematic review and meta-analysis. European Journal of Gastroenterology Hepatology. 2021;33:e851-57.

Sey M, Yan B, McDonald C, Segal D, Friedland J, Puka K, Jairath V. A randomized controlled trial of high volume simethicone to improve visualization during capsule endoscopy. PLoS One. 2021;16(4):e0249490. 

Wilson A, Wang Q, Choi YH, Ponich T, Gregor JC, Chande N, Yan B, Sey M, Beaton M, Kim RB. Pretreatment HLADQA1-HLADRB1 Testing for the Prevention of Azathioprine-Induced Pancreatitis in Inflammatory Bowel Disease: A Prospective Cohort Study. Clin Transl Gastroenterol. 2021;12(4):e00332. 

Wilson A, Choi B, Sey M, Ponich T, Beaton M, Kim RB. High infliximab trough concentrations are associated with sustained histologic remission in inflammatory bowel disease: a prospective cohort study. BMC Gastroenterol. 2021 Feb 18;21(1):77.

Oakland K, Kothiwale S, Forehand T, Jackson E, Bucknall C, Sey M, Singh S, Jairath V, Perlin JB. External validation of the Oakland score for acute lower gastrointestinal bleeding. JAMA Network Open 2020;3:e209630.

Barkun A, Bardou M, Martel M, Epstein I, Halle P, Hilsden R, James PD, Rostom A, Sey M, Singh H, Sultanian R, Telford J, Von Renteln D. The Bowel CLEANsing National Initiative (BCLEAN): A Low-Volume Same-day Polyethylene Glycol (PEG) Preparation versus Low-Volume Split-Dose PEG with Bisacodyl or High-Volume Split-Dose PEG Preparations – A randomized controlled trial. American Journal of Gastroenterology 2020:115;2068-76.

Alageeli M, Yan B, Alshankiti S, Al-Zahrani M, Bahreini Z, Dang T, Friedland J, Gilani S, Homenauth R, Houle J, Kloc M, Luhoway J, Merotto L, Rofaiel R, Singh C, Smith A, Thomas B, Townsend C, Yoo D, Zepeda-Gomez S, Stitt L, Jairath V, Sey M. KODA score: an updated and validated bowel preparation scale for patients undergoing small bowel capsule endoscopy. Endoscopy International Open 2020;8:E1011-1017.

Al-Judaibi B, Alqalami I, Sey M, Qumosani K, Howes N, Chandok N, Eddin A, Hernandez-Alejandro R, Marotta P, Teriaky A. Exercise training for liver transplant candidates. Transplant Proc. 2019;51:3330-3337.

Al DraiweeshS, Ma C, Alkhattabi M, McDonald C, Nguyen T, Beaton M, Chande N, Colquhoun P, Feagan B, Gregor J, Khanna R, Marotta P, Ponich T, Quan D, Qumosani K, Sandhu A, Sey M, Skaro A, Teriaky A, Wilson A, Yan B, Brahmania M, Jairath V. Safety of combination biologic and anti-rejection therapy post-liver transplantation in patients with IBD. Inflamm Bowel Dis 2020;26:949-59.

Sey M, Von Renteln D, Sultanian R, McDonald C, Martel M, Barkun A.  A study protocol for a multi-centre endoscopist blinded randomized clinical trial to compare two bowel preparations after a colonoscopy with inadequate cleansing.  BMJ Open. 2019;9:e029573.

Sey M, Yan B. Optimal management of the patient presenting with small bowel bleeding. Best Pract Res Clin Gastroenterol. 2019;42-43:101611. Review.

Rush B, Deol N, Teriyaki A, Sey M, Jairath V, Walley KR, Celi LA, Brahmania M. Lower 90-day hospital readmission rates for esophageal variceal bleeding after TIPS: a nationwide linked analysis. J Clin Gastroenterol. 2019;54:90-95.

Sey MS, Seid BM, Brahmania M, Singh Siddharth, Kahan BC, Jairath V. Comparative outcomes in patients with ulcer versus non-ulcer related acute upper gastrointestinal bleeding: a nationwide cohort of 4478 patients.  Aliment Pharmacol Ther 2019;49:537-45.

Oakland K, Kahan BC, Guizzetti L, Martel M, Bryant RV, Brahmania M, Singh S, Nguyen N, Sey MSL, Barkun A, Jairath V.  1.  Development, Validation, and Comparative Assessment of an International Scoring System to Determine Risk of Upper Gastrointestinal Bleeding.  Clin Gastroenterol Hepatol. 2019;17:1121-29.

Kherad O, Restellini S, Martel M, Sey M, Murphy M, Oakland K, Barkun A, Jairath V. Outcomes following restrictive or liberal red blood cell transfusion in patients with lower gastrointestinal bleeding. Aliment Pharmacol Ther. 2019;49:919-25.

Ufere N, Brahmania M, Sey M, Teriaky A, El-Jawahri A, Walley K, Celi L, Chung R, Rush B. Poor outcomes of in-hospital cardiopulmonary resuscitation for patients with end-stage liver disease. Liver Int. 2019;39:1256-62

Bougie O, Zuckerman SL, Switzer N, How J, Sey M. Influence of Resident Involvement in Obstetrics and Gynaecology Surgery on Surgical Outcomes: Systematic Review and Meta-Analysis.  J Obstet Gynaecol Can 2018;17: 30973-8.

Zhu CN, Friedland J, Yan B, Wilson A, Gregor J, Jairath V, Sey M.  Presence of Melena in Obscure Gastrointestinal Bleeding Predicts Bleeding in the Proximal Small Intestine.  Dig Dis Sci 2018;63:1280-1285.

Wilson A, Jansen LE, Rose RV, Gregor JC, Ponich T, Chande N, Khanna R, Yan B, Jairath V, Khanna N, Sey M, Beaton M, McIntosh K, Teft WA, Kim RB. Predicting azathioprine-associated pancreatitis in IBD-phenotype or genotype? Aliment Pharmacol Ther 2018;47:1044-1045.

Ing EB, Ing R, Liu X, Zhang A, Torun N, Sey M, Pagnoux C.  Does herpes zoster predispose to giant cell arteritis: a geo-epidemiologic study.  Clin Ophthalmol 2018;12:113-118.

Wilson A, Jansen L, Rose R, Gregor J, Ponich T, Chande N, Khanna R, Yan B, Jairath V, Khanna N, Sey M, Beaton M, McIntosh K, Teft W, Kim R.  HLA-DQA1-HLA-DRB1 polymorphism is a major predictor of azathioprine-induced pancreatitis in patients with inflammatory bowel disease.  Aliment Pharmacol & Ther.  2018;47:615-620.

Sey M, Gregor H, Gregor J, Yan B. Insertion of percutaneous endoscopic gastrostomy tubes with jejunal extensions (PEG-J) using the wedge technique – a novel method to prevent retrograde tube migration into the stomach.  Endoscopy. 2017;49:1251-55.

Yan BM, Feagan B, Teriaky A, Mosli M, Mohamed R, Williams GS, Yeung E, Yong E, Haig A, Sey M, Stitt L, Zou GY, Jairath V. Reliability of EUS indices to detect inflammation in ulcerative colitis. Gastrointest Endosc. 2017;86:1079-87.

Sey M, Liu A, Asfaha S, Siebring V, Jairath V, Yan B. Performance report cards increase adenoma detection rate.  Endosc Int Open. 2017 Jul;5(7):675-682.

Sey M, Al-Haddad M, Imperiale T, McGreevy K, Lin J, DeWitt J.  Endoscopic ultrasound guided liver biopsy for parenchymal disease: a comparison of diagnostic yield between two core biopsy needles.  Gastrointestinal Endoscopy. 2016;83:347-52.

Sey M, Teagarden S, Settles D, Al-Haddad M, LeBlanc JK, McGreevy K, Cote G, Sherman S, McHenry L, DeWitt J. Prospective cross sectional study of the prevalence of pancreatic cysts during routine outpatient endoscopic ultrasound. Pancreas. 2015;44:1130-3.

Sey M, Higgins L, DeWitt J, Lassisi A, Juan M, Sherman S, McHenry L, Imperiale T, LeBlanc JK. Effectiveness and safety of serial endoscopic ultrasound-guided celiac plexus block and neurolysis for chronic pancreatitis and cancer-related pain.  Endoscopy Int Open. 2015;3:E56-9.

Nakanishi Y, Mneimneh W, Sey M, Al-Haddad M, DeWitt J, Saxena R. One hundred thirteen consecutive transgastric liver biopsies for hepatic parenchymal diseases: a single-institution study. American Journal of Surgical Pathology. 2015;39:968-76.

Sey M, DeWitt J, Al-Haddad M. EUS in Pancreatic Tumors.  In: ERCP and EUS: A Case Based Approach. Springer Publishing; 2015.

Luz L, Sey M, Al-Haddad M, DeWitt J. Application of EUS in pancreatic cancer. World J Gastroenterol. 2014;29:7808-18.

Lam MCW, Sey M, Gregor J, Wong C.  Follow-up on 2006-2012 participants of the Canadian Association of Gastroenterology Scholars’ Program. Can J Gastroenterol Hepatol. 2014;28:94-96.

Sey M, DeWitt J. A ‘tuft’ procedure. Endoscopy. 2013;45:E375.

Sey M. Bariatric Surgery for the Gastroenterologist. In: Thomson ABR, Chande N (Eds). Medical Mini Review Series in Gastroenterology and Hepatology: Efficient Refresher for the Busy Clinical Gastroenterologist. CAPstone Publishing; 2013.

Sey M, Gregor J, Chande N, Ponich T, Bhaduri M, Lum PA, Zaleski W, Yan B. Diagnostic accuracy of bowel ultrasound in inflammatory bowel disease: A North American perspective.  J Ultrasound Med. 2013;32:1413–1417.

Sey M, Gregor J, Adams P, Khanna N, Vinden C, Driman D, Chande N. Wait times for diagnostic colonoscopy among outpatients with colorectal cancer: A comparison with Canadian Association of Gastroenterology targets. Can J Gastroenterol. 2012;26:894-896.

Sey M, Parfitt J, Gregor J. Prospective study of clinical and histological safety of pure and uncontaminated Canadian oats in the management of celiac disease. JPEN J Parenter Enteral Nutr. 2011;35:459-64.

Gregor J, Sey M. Celiac Disease. In: McDonald JWD, Burroughs AK, Feagan BG, Fennerty B (Eds.), Evidence Based Gastroenterology and Hepatology (3^rd ed.). Oxford: Wiley-Blackwell Publishing; 2010.