CNS Research Day 2019
The Department of Clinical Neurological Sciences hosted its 2019 Departmental Research Day on May 14th, 2019 at Kings University College. This annual event features platform and poster presentations by residents, graduate students, PhD candidates, and postdoctoral fellows. Dr. Derek Debicki, Dr. Michael Mayich, and special guest Dr. Sheila Singh judged the 16 platform presentations and 44 poster presentations.
The 2019 CNS Research Day Award Winners were the following:
Best Platform – Neurology: Michael Krawczyk on Atrial fibrillation diagnosed after stroke and increased risk of dementia: a multicenter cohort study.
Thank you to everyone who submitted their research as well as the faculty members who have provided guidance and encouragement to these up and coming researchers.
Keynote Speaker
Dr. Sheila Singh
Title: Therapeutic targeting of brain cancer stem cells: A personalized medicine approach to treatment-resistant brain cancer
Dr. Singh is a Professor of Surgery and Biochemistry, Chief Pediatric Neurosurgeon at McMaster Children’s Hospital and the Division Head of Neurosurgery at Hamilton Health Sciences and Scientist appointed to the Stem Cell and Cancer Research Institute at McMaster University. She holds a Tier One Senior Canada Research Chair in Human Brain Cancer Stem Cell Biology and is Director of the McMaster Surgeon Scientist Program.
Her PhD thesis described the novel identification of a population of cancer stem cells that exclusively drive the formation of brain tumours. Since 2007, Dr. Singh's lab applies a developmental neurobiology framework to the study of brain tumorigenesis. Building upon previous cell culture techniques developed for the isolation of normal neural stem cells (NSC) and applying them to brain tumours, and through development of a xenograft model to efficiently study brain tumour initiating cell (BTIC) activity, Dr. Singh's lab aims to understand the molecular mechanisms that govern BTIC selfrenewal.
Dr. Singh is currently studying the regulation of BTIC signaling pathways in glioblastoma, brain metastases and childhood medulloblastoma, with an ultimate goal of selectively targeting the BTIC with appropriately tailored drug and molecular therapies. Her laboratory is funded by CCSRI, CIHR, TFRI, CRS, the Stem Cell Network, McMaster Surgical Associates, Brain Canada and the Boris Family Fund.