Publications

Kim MKM, Ramachandran R, Séguin CA. (2021) Spatiotemporal and functional characterisation of transient receptor potential vanilloid 4 (TRPV4) in the murine intervertebral disc. Eur Cell Mater, doi: 10.22203/eCM.v041a14

Kerr GJ, To B, White I, Millecamps M, Beier F, Grol MW, Stone LS, Séguin CA. (2021) Diet-induced obesity leads to behavioral indicators of pain preceding structural joint damage in wild-type mice. Arthritis Res Ther. doi: 10.1186/s13075-021-02463-5

Groh AMR, Fournier DE, Battié MC, Séguin CA. (2021) Innervation of the human intervertebral disc: a scoping review. Pain Med. doi: 10.1093/pm/pnab070

Noonan AM, Séguin CA, Brown SHM. (2021) Paraspinal muscle contractile function is impaired in the ENT1-deficient mouse model of progressive spine pathology. Spine, doi: 10.1097/BRS.0000000000003882

Fournier DE, Kiser PK, Beach RJ, Dixon SJ, Séguin CA. (2020) Dystrophic calcification and heterotopic ossification in fibrocartilaginous tissues of the spine in diffuse idiopathic skeletal hyperostosis (DISH). Bone Res. doi: 10.1038/s41413-020-0091-6

Serjeant ME, Moon PM, Quinonez D, Penuela S, Beier F, Séguin CA. (2020) The role of Panx3 in age-associated and injury-induced intervertebral disc degeneration. Int J Mol Sci. doi: 10.3390/ijms22031080

Kim MKM, Burns MJ, Serjeant ME, Séguin CA. (2020) The mechano-response of murine annulus fibrosus cells to cyclic tensile strain is frequency dependent. JOR Spine, doi: 10.1002/jsp2.1114

Fournier DE, Kiser PK, Shoemaker JK, Battié MC, Séguin CA. (2020) Vascularization of the human intervertebral disc: A scoping review. JOR Spine, doi;10.1002/jsp2.1123

Veras MA, Lim YJ, Kuljanin M, Lajoie GA, Urquhart BL, Séguin CA. (2020) Protocol for parallel proteomic and metabolomic analysis of mouse intervertebral disc tissues. JOR Spine, doi: 10.1002/jsp2.1099

Veras MA, McCann MR, Tenn NA, Séguin CA. (2020) Transcriptional profiling of the murine intervertebral disc and age-associated changes in the nucleus pulposus. Connective Tissue Research, doi: 10.1080/03008207.2019.1665034

Fournier DE, Kiser PK, Beach RJ, Dixon SJ, Séguin CA. (2020) Dystrophic calcification and heterotropic ossification in fibrocartilaginous tissues of the spine in diffuse idiopathic skeletal hyperostosis (DISH).  Bone Res, doi: 10.1038/s41413-020-0091-6

Esseltine JL, Brooks C, Edwards NA, Subasri M, Sampson J, Séguin CA, Betts DH, Laird DW. (2019) Dynamic regulation of connexins in stem cell pluripotency. Stem Cells, doi; 10.1002/stem.3092

Fournier DE, Norley CJD, Pollman, SI, Bailey CS, Helal FA, Willmore KE, Holdsworth DW, Dixon SJ, Séguin CA. (2019) Ectopic spinal calcification associated with diffuse idiopathic skeletal hyperostosis (DISH): a quantitative micro-ct analysis.  J Orthop Res, doi: 10.1002/jor.24247

Ulici V, Kelley KL, Longobardi L, McNulty MA, Livingston EW, Bateman TA, Séguin CA, Louer CR, Loeser RF. (2018) Impaired Annulus Fibrosus Development and Vertebral Fusion Cause Severe Scoliosis in Mice with Deficiency of JNK1 and JNK2. Am J Pathol, doi: 10.1016/j.ajpath.2018.12.010

Séguin CA, Chan D, Dahia CL, Gazit Z. (2018) Latest advances in intervertebral disc development and progenitor cells. JOR Spine, doi: 10.1002/jsp2.1030

Zheng L, Cao Y, Ni S, Qi H, Ling Z, Xu X, Zou X, Wu T, Deng R, Hu B, Gao B, Chen H, Li Y, Zhu J, Tintani F, Demehri S, Jain A, Kebaish KM, Liao S, Séguin CA, Crane JL, Wan M, Lu H, Sponseller PD, Riley LH 3rd, Zhou X, Hu J, Cao X. (2018) Ciliary parathyroid hormone signaling activates transforming growth factor-B to maintain intervertebral disc homeostasis during aging. Bone res, doi: 10.1038/s41413-018-0022-y

Tam V, Chan WCW, Leung VYL, Cheah KSE, Cheung KMC, Sakai D, McCann MR, Bedore J, Séguin CA, Chan D. (2017) Histological and reference system for the analysis of mouse intervertebral disc. J Orthop Res, doi: 10.1002/jor.23637. [Epub ahead of print]

Bian Q, Ma L, Jain A, Crane JL, Kebaish K, Wan M, Zhang Z, Edward Guo X, Sponseller PD, Séguin CA, Riley LH, Wang Y, Cao X. (2017) Mechanosignaling activation of TGFB maintains intervertebral disc homeostasis. Bone Res, 5:17008

Gsell KY, Zwambag DP, Fournier DE, Séguin CA, Brown SH. (2017) Paraspinal Muscle Passive Stiffness Remodels in Direct Response to Spine Stiffness: A Study Using the ENT1 Deficient Mouse. Spine (Phila Pa 1976), doi: 10.1097/BRS.0000000000002132. [Epub ahead of print].

Esseltine JL, Shao Q, Brooks C, Sampson J, Betts DH, Séguin CA, Laird DW. (2017) Connexin43 Mutant Patient-Derived Induced Pluripotent Stem Cells Exhibit Altered Differentiation Potential. J Bone Miner Res, 32(6):1368-1385.

McCann MR, Veras MA, Yeung C, Lalli G, Patel P, Leitch KM, Holdsworth DW, Dixon SJ, Séguin CA. (2017) Whole-body vibration of mice induces progressive degeneration of intervertebral discs associated with increased expression of IL-1B and multiple matrix degrading enzymes. Osteoarthritis Cartilage, 25(5):779-789.

Kerr GJ, McCann MR, Branch JK, Ratneswaran A, Pest MA, Holdsworth DW, Beier F, Dixon SJ, Séguin CA. (2017) C57BL/6 mice are resistant to joint degeneration induced by whole-body vibration. Osteoarthritis Cartilage, 25(3):421-425.

Kerr GJ, Veras MA, Kim MK, Séguin CA. (2017) Decoding the intervertebral disc: Unravelling the complexities of cell phenotypes and pathways associated with degeneration and mechanotransduction. Semin Cell Dev Biol, 62:94-103.

Veras MA, Tenn NA, Kuljanin M, Lajoie GA, Hammond JR, Dixon SJ, Séguin CA. (2017) Loss of ENT1 increases cell proliferation in the annulus fibrosus of the intervertebral disc.  J Cell Physiol, doi:  10.1002/jcp.28051

McCann MR, Yeung C, Pest MA, Ratneswaran A, Pollmann SI, Holdsworth DW, Beier F, Dixon SJ, Séguin CA. (2016) Whole-body vibration of mice induces articular cartilage degeneration with minimal changes in subchondral bone. Osteoarthritis and Cartilage, doi: 10.1016/j.joca.2016.11.001 

Tobias IC, Brooks CR, Teichroeb JH, Villagoméz DA, Hess DA, Séguin CA, Betts DH. (2016) Small-Molecule Induction of Canine Embryonic Stem Cells Toward Naive Pluripotency. Stem Cells Dev, 25(16):1208-1222.

McCann MR, Séguin CA. (2016) Notochord Cells in Intervertebral Disc Development and Degeneration. J Dev Biol, 4(1):1-18.

Ii H, Warraich S, Tenn N, Quinonez D, Holdsworth DW, Hammond JR, Dixon SJ, Séguin CA. (2016) Disruption of biomineralization pathways in spinal tissues of a mouse model of diffuse idiopathic skeletal hyperostosis. Bone, 90:37-49.

Bedore J, Quesnel K, Quinonez D, Séguin CA, Leask A. (2016) Targeting the annulus fibrosus of the intervertebral disc: Col1a2-Cre(ER)T mice show specific activity of Cre recombinase in the outer annulus fibrosus. J Cell Commun Signal, 10(2):137-42.

McCann MR, Patel P, Pest MA, Ratneswaran A, Lalli G, Beaucage KL, Backler GB, Kamphuis MP, Esmail Z, Lee J, Barbalinardo M, Mort JS, Holdsworth DW, Beier F, Dixon SJ, Séguin CA. (2015) Repeated exposure to high-frequency low-amplitude vibration induces degeneration of murine intervertebral discs and knee joints. Arthritis Rheumatol, 67(8):2164-75. 

McCann MR, Patel P, Frimpong A, Xiao Y, Siqueira WL, Séguin CA. (2015) Proteomic signature of the murine intervertebral disc. PLoS One, 10(2):e0117807.