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Total number of publications: 81

Dr. Bai's citation information from Web of Science and Google Scholar

Total number of citations: 3764 (5460)

h-index: 31 (36)

Number of publications with at least 10 citations: 64 (68)

Full Publication list of Donglin Bai on PubMed

Full publication list

(*Corresponding author; underlined authors are trainees I supervised)

  1. Leighton, S.E., Wong, R.S., Lucaciu, S.A., Hauser A., Johnston, D., Stathopulos, P.B., Bai, D., Penuela, S., and Laird, D.W. (2024) Cx31.1 can selectively intermix with co-expressed connexins to facilitate its assembly into gap junctions. J Cell Sci (accepted)
  2. Wong, R.S., Chen, H., Li, Y.X., Esseltine J.L., Stathopulos, P.B., Bai, D.* (2024) Human Cx50 isoleucine177 prevents heterotypic docking and formation of functional gap junction channels with Cx43. Am J Physiol Cell Physiol 326, C414-C428
  3. Li, T., Chen H., Li, X., Stathopulos, P.B. and Bai, D.* (2023) Inherited disease-linked arginine76/75 mutants in Cx50 and Cx45 showed impaired homotypic and heterotypic gap junction function, but not Cx43. Biochem J 480, 1051 - 1077
  4. Li, Y.-J.; Wang, J.; Ye, W.G.; Liu, X-Y., Li, L.; Qiu, X.-B; Chen, H.; Xu, Y.-J.; Yang, Y.-Q.*; Bai, D.*; Huang, R.-T.* (2023) Discovery of GJC1 (Cx45) as a new gene underlying congenital heart disease and arrhythmias. Biology 12, 346 (1-20)
  5. Lucaciu, S.A., Figliuzzi, R., Neumann, R., Nazarali, S. Del Sordo, L., Leighton, S. Hauser, A., Shao, Q., Johnston, D., Bai, D., and Laird, D.W. (2023) GJB4 variants linked to skin disease exhibit a trafficking deficiency en route to gap junction formation that can be restored by co-expression of select connexins. Frontiers in Cell and Developmental Biology 11, 1073805 https://doi.org/10.3389/fcell.2023.1073805
  6. Jaradat, R.; Li, X., Chen, H., Stathopulos, P.B. and Bai, D.* (2022) The hydrophobic residues in amino terminal domains of Cx46 and Cx50 are important for their gap junction channel ion permeation and gating. Int J Mol Sci 23, 11605 (1-22)
  7. Lucaciu, S.A., Shao, Q., Figliuzzi, R., Barr, K., Bai, D. and Laird, D.W. (2022) Interrogation of carboxy-terminus localized GJA1 variants associated with erythrokeratodermia variabilis et progressiva. Int J Mol Sci 23, 486 (1-16)
  8. Bai, D.*, Wang, J., Li, T., Chan, R., Atalla, M., Chen, R.C., Khazaneh, M.T., An, R.J., Stathopulos, P.B. (2021) Differential domain distribution of gnomAD- and disease-linked connexin missense variants. Int J Mol Sci 22, 7832 (1-23)
  9. Yue, B., Haddad, B.G, Khan, U., H., Atalla, M., Zhang, Z., Zuckerman, D.M., Reichow, S.L.* and Bai, D* (2021) Connexin 46 and connexin50 gap junction channel properties are shaped by structural and dynamic features of their N-terminal domains. J Physiol 599, 3313-3335
  10. Li, Y.J. Xu, W.G. Ye, Y.J. Li, H. Chen, X.B. Qiu, Y.-Q. Yang,* and D. Bai* (2021) Connexin45 (GJC1) loss-of-function mutation contributes to familial atrial fibrillation and conduction disease. Heart Rhythm 18, 684 - 693
  11. Santos-Miranda, A., Chen, H., Chen, R.C., Odoko-Ishimoto, M., Aoyama, H. and Bai, D.* (2020) The amino terminal domain plays an important role in transjunctional voltage-dependent gating kinetics of Cx45 gap junctions. J Mol Cell Card 143, 73-84
  12. Santos-Miranda, A., Noureldin, M. and Bai, D* (2019) Effects of temperature on transjunctional voltage-dependent gating kinetics in Cx45 and Cx40 gap junction channels. J Mol Cell Card 127, 185-193
  13. Kim, N.K., Santos-Miranda, A., Chen, H., Aoyama, H. and Bai, D.* (2019) Heterotypic docking compatibility of human connexin37 with other vascular connexins. J Mol Cell Card 127, 194-203
  14. Tejada, M.G., Sudhakar, S., Kim, N.K., Aoyama, H., Shilton, B.H. and Bai, D.* (2018) Variants with increased negative electrostatic potential in the Cx50 gap junction pore increased unitary channel conductance and magnesium modulation. Biochem J 475, 3315-3330
  15. Noureldin, M., Chen, H. and Bai, D* (2018) Functional characterization of novel lone atrial fibrillation-linked GJA5 (Cx40) mutants. Int J Mol Sci 19, 977 (1-16)
  16. Bai, D.*, Yue, B. and Aoyama, H. (2018) Crucial motifs and residues in the extracellular loops influence the specificity of connexin docking. Biochim Biophys Acta – Biomembranes 1860, 9-21
  17. Ye, W.G., Yue, B., Aoyama, H., Kim, N.K., Cameron, J.A., Chen, H. and Bai, D.* (2017 Junctional delay, frequency, and direction-dependent uncoupling of human heterotypic Cx45/Cx43 gap junction channels. J Mol Cell Card 111, 17-26
  18. Kelly J.J., Esseltine, J., Shao, Q., Wang Jabs, E., Sampson, J., Auranen, M., Bai, D. and Laird, D.W. (2016) Specific functional pathologies of Cx43 mutations associated with oculodentodigital dysplasia. Mol Biol Cell online published: DOI: 10.1091/mbc.E16-01-0062
  19. Karademir, L., Aoyama, H., Yue, B., Chen, H. and Bai, D.* (2016) Engineered Cx26 variant established functional heterotypic Cx26/Cx43 and Cx26/Cx40 gap junction channels. Biochem J 473, 1391-1403
  20. Bai, D.* (2016) Structural analysis of key gap junction domains – lessons from genome data and disease-linked mutants. Semin Cell Dev Biol 50, 74-82
  21. Jassim, A., Aoyama, H., Ye, W.G., Chen, H. and Bai, D.* (2016) Engineered Cx40 variants increased docking and function of heterotypic Cx40/Cx43 gap junction channels. J Mol Cell Card 90, 11-20
  22. Tong, X., Aoyama, H., Sudhakar, S., Chen, H., Shilton, B.H. and Bai, D.* (2015) The first extracellular domain plays an important role in unitary channel conductance of Cx50 gap junction channels. PLoS One 10 (12) e43876
  23. Tong, X., Aoyama, H., Tsukihara, T. and Bai, D.* (2014) Charge at the 46th residue of Cx50 is crucial for the gap junctional unitary conductance and transjunctional voltage-dependent gating. J Physiol 592, 5187-5202
  24. Sun, Y., M.D. Hills, Ye, W.G., X. Tong and Bai, D.* (2014) Atrial fibrillation-linked connexin40 mutants increase hemichannel activities. PLoS One 9 (4) e95125
  25. Sun, Y., X. Tong, H. Chen, T. Huang; Q. Shao; W. Huang, D.W. Laird and Bai, D.* (2014) An atrial-fibrillation-linked connexin40 mutant is retained in the endoplasmic reticulum and impairs the function of atrial gap-junction channels. Dis Model Mech 7, 561-569
  26. Bai, D.* (2014) Atrial fibrillation-linked GJA5/connexin40 mutants impair gap junctions via different mechanisms. FEBS Lett 588, 1238-1243 (invited review)
  27. Bai, D.* and Wang, A.H. (2014) Extracellular domains play different roles in gap junction formation and docking compatibility. Biochem J 458, 1-10 (invited review)
  28. Xin, L. and Bai, D.* (2013) Functional roles of the amino terminal domain in determining biophysical properties of Cx50 gap junction channels. Front Physiol 4, 373, 1-7 (invited review)
  29. H.X. Wang, S.L. Chen, X.Q. Gong, T.Y. Li, D. Bai and G.M. Kidder, (2013) The Canonical WNT pathway and FSH interact to regulate gap junction assembly in mouse granulosa cells.  Bio Reprod 89, 1-7
  30. Gong, X.Q., Nakagawa, S., Tsukihara, T. and Bai, D.* (2013) A gap junction docking mechanism revealed by functional rescue of a human disease-linked connexin mutant. J Cell Sci 126, 3113-3120 (selected as one of the featured articles in this issue)
  31. Kim, M.S. Gloor, G.B. and Bai, D.* (2013) The distribution and functional properties of Pelizaeus Merzbacher-like disease-linked Cx47 mutations on Cx47/Cx47 homotypic and Cx47/Cx43 heterotypic gap junctions. Biochem J 452, 249-258
  32. Huang, T., Shao, Q., MacDonald, A., Xin, L., Lorentz, R., Bai, D. and Laird, D.W. (2013) Autosomal recessive GJA1 (Cx43) gene mutations cause oculodentodigital dysplasia by distinct mechanisms. J Cell Sci 126, 2857-2866
  33. Sun, Y., Yang, Y.Q., Gong, X.Q., Wang, X.H., Li, R.G., Tan, H.W., Fang, W.Y. and Bai, D.* (2013) Novel germline GJA5/connexin40 mutations associated with lone atrial fibrillation impair gap junctional intercellular communication. Hum Mutat 34, 603-609
  34. Stewart, M.K.G., Gong, X.Q., Barr, K.J., Bai, D., Fishman, G.I. and Laird, D.W. (2013) The severity of mammary gland developmental defects is linked to the overall functional status of Cx43 as revealed by genetically-modified mice. Biochem J 449, 401-413
  35. Xin, L., Sun, Y. and Bai, D.* (2012) Heterotypic connexin50/connexin50 mutant gap junction channels reveal interactions between two hemichannels during transjunctional voltage-dependent gating. J Physiol 590, 5037-5052
  36.    Shao, Q., Liu, Q., Lorentz, R., Gong, X.G., Bai, D., Shaw, G.S. and Laird, D.W. (2012) Structure and functional studies of N-terminal Cx43 mutants linked to oculodentodigital dysplasia. Mol Biol Cell 23, 3312-3321
  37.    Churko, JM, Kelly, JJ, MacDonald, A, Lee, J, Sampson, J, Bai, D. and Laird, DW (2012) The G60S Cx43 mutant enhances keratinocyte proliferation and differentiation. Exp Dermatol 21, 612-618
  38. Xin, L., Nakagawa, S., Tsukihara, T. and Bai, D.* (2012) Aspartic acid residue D3 critically determines Cx50 gap junction channel transjunctional voltage-dependent gating and unitary conductance. Biophys J 102, 1022-1031
  39.   Nakagawa, S., Gong, X.Q., Maeda, S., Dong, Y., Misumi, Y., Tsukihara, T. and Bai, D.* (2011) Asparagine175 of connexin32 is a critical residue for docking and forming functional heterotypic gap junction channels with connexin26. J Biol Chem 286, 19672-19681
  40. Churko, J.M., Shao, Q., Gong, X.G., Swoboda, K.J., Bai, D., Sampson, J., and Laird, D.W. (2011). Human dermal fibroblasts derived from oculodentodigital dysplasia patients suggest that patients may have wound healing defects. Hum Mutat 32, 456-466
  41. Xin, L., Gong, X.Q., and Bai, D.* (2010). The role of amino terminus of mouse Cx50 in determining transjunctional voltage-dependent gating and unitary conductance. Biophys J 99, 2077-2086.
  42. Gan, X.T., Gong, X.Q., Xue, J., Haist, J.V., Bai, D., and Karmazyn, M. (2010). Sodium-hydrogen exchange inhibition attenuates glycoside-induced hypertrophy in rat ventricular myocytes. Cardiovasc Res 85, 79-89.
  43. Tong, D., Colley, D., Thoo, R., Li, T.Y., Plante, I., Laird, D.W., Bai, D., and Kidder, G.M. (2009). Oogenesis defects in a mutant mouse model of oculodentodigital dysplasia. Dis Model Mech 2, 157-167.
  44. Tong, D., Lu, X., Wang, H.X., Plante, I., Lui, E., Laird, D.W., Bai, D., and Kidder, G.M. (2009). A dominant loss-of-function GJA1 (Cx43) mutant impairs parturition in the mouse. Biol Reprod 80, 1099-1106.
  45. Manias, J.L., Plante, I., Gong, X.Q., Shao, Q., Churko, J., Bai, D., and Laird, D.W. (2008). Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant. Cardiovasc Res 80, 385-395.
  46. Gong, X.Q., Shao, Q., Langlois, S., Bai, D.*†, and Laird, D.W.† (2007). Differential potency of dominant negative connexin43 mutants in oculodentodigital dysplasia. J Biol Chem 282, 19190-19202.
  47. Tong, D., Li, T.Y., Naus, K.E., Bai, D., and Kidder, G.M. (2007). In vivo analysis of undocked connexin43 gap junction hemichannels in ovarian granulosa cells. J Cell Sci 120, 4016-4024.
  48. Penuela, S., Bhalla, R., Gong, X.Q., Cowan, K.N., Celetti, S.J., Cowan, B.J., Bai, D., Shao, Q., and Laird, D.W. (2007). Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins. J Cell Sci 120, 3772-3783.
  49. Gong, X.Q., Zabek, R.L., and Bai, D.* (2007). D-Serine inhibits AMPA receptor-mediated current in rat hippocampal neurons. Can J Physiol Pharmacol 85, 546-555.
  50. Bai, D., del Corsso, C., Srinivas, M., and Spray, D.C. (2006). Block of specific gap junction channel subtypes by 2-aminoethoxydiphenyl borate (2-APB). J Pharmacol Exp Ther 319, 1452-1458.
  51. Gong, X.Q., Shao, Q., Lounsbury, C.S., Bai, D., and Laird, D.W. (2006). Functional characterization of a GJA1 frameshift mutation causing oculodentodigital dysplasia and palmoplantar keratoderma. J Biol Chem 281, 31801-31811.
  52. Gollob, M.H., Jones, D.L., Krahn, A.D., Danis, L., Gong, X.Q., Shao, Q., Liu, X., Veinot, J.P., Tang, A.S., Stewart, A.F., Tesson, F., Klein, G.J., Yee, R., Skanes, A.C., Guiraudon, G.M., Ebihara, L., and Bai, D. (2006). Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation. N Engl J Med 354, 2677-2688.
  53. Tong, D., Gittens, J.E., Kidder, G.M., and Bai, D.* (2006). Patch-clamp study reveals that the importance of connexin43-mediated gap junctional communication for ovarian folliculogenesis is strain specific in the mouse. Am J Physiol Cell Physiol 290, C290-297.
  54. McLachlan, E., Manias, J.L., Gong, X.Q., Lounsbury, C.S., Shao, Q., Bernier, S.M., Bai, D., and Laird, D.W. (2005). Functional characterization of oculodentodigital dysplasia-associated Cx43 mutants. Cell Commun Adhes 12, 279-292.
  55. Flenniken, A.M., Osborne, L.R., Anderson, N., Ciliberti, N., Fleming, C., Gittens, J.E., Gong, X.Q., Kelsey, L.B., Lounsbury, C., Moreno, L., Nieman, B.J., Peterson, K., Qu, D., Roscoe, W., Shao, Q., Tong, D., Veitch, G.I., Voronina, I., Vukobradovic, I., Wood, G.A., Zhu, Y., Zirngibl, R.A., Aubin, J.E., Bai, D., Bruneau, B.G., Grynpas, M., Henderson, J.E., Henkelman, R.M., McKerlie, C., Sled, J.G., Stanford, W.L., Laird, D.W., Kidder, G.M., Adamson, S.L., and Rossant, J. (2005). A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development 132, 4375-4386.
  56. Gong, X.Q., Frandsen, A., Lu, W.Y., Wan, Y., Zabek, R.L., Pickering, D.S., and Bai, D.* (2005). D-aspartate and NMDA, but not L-aspartate, block AMPA receptors in rat hippocampal neurons. Br J Pharmacol 145, 449-459.
  57. Roscoe, W., Veitch, G.I., Gong, X.Q., Pellegrino, E., Bai, D., McLachlan, E., Shao, Q., Kidder, G.M., and Laird, D.W. (2005). Oculodentodigital dysplasia-causing connexin43 mutants are non-functional and exhibit dominant effects on wild-type connexin43. J Biol Chem 280, 11458-11466.
  58. Kolaj, M., Bai, D., and Renaud, L.P. (2004). GABAB receptor modulation of rapid inhibitory and excitatory neurotransmission from subfornical organ and other afferents to median preoptic nucleus neurons. J Neurophysiol 92, 111-122.
  59. Sattelle, D.B., Bai, D., Chen, H.H., Skeer, J.M., Buckingham, S.D., and Rauh, J.J. (2003). Bicuculline-insensitive GABA-gated Cl- channels in the larval nervous system of the moth Manduca sexta. Invert Neurosci 5, 37-43.
  60. Bai, D.*, Muller, R.U., and Roder, J.C. (2002). Non-ionotropic cross-talk between AMPA and NMDA receptors in rodent hippocampal neurones. J Physiol 543, 23-33.
  61. Bai, D., Zhu, G., Pennefather, P., Jackson, M.F., MacDonald, J.F., and Orser, B.A. (2001). Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons. Mol Pharmacol 59, 814-824.
  62. Toong, S., Xiong, Z.G., Zavorin, S.I., Bai, D., Orser, B.A., Thatcher, G.R., Reynolds, J.N., and MacDonald, J.F. (2001). Modulation of AMPA receptors by a novel organic nitrate. Can J Physiol Pharmacol 79, 422-429.
  63. Sattelle, D.B., Harrison, J.B., Chen, H.H., Bai, D., and Takeda, M. (2000). Immunocytochemical localization of putative gamma-aminobutyric acid receptor subunits in the head ganglia of Periplaneta americana using an anti-RDL C-terminal antibody. Neurosci Lett 289, 197-200.
  64. Lu, W.Y., Jackson, M.F., Bai, D., Orser, B.A., and MacDonald, J.F. (2000). In CA1 pyramidal neurons of the hippocampus protein kinase C regulates calcium-dependent inactivation of NMDA receptors. J Neurosci 20, 4452-4461.
  65. Lei, S., Jackson, M.F., Jia, Z., Roder, J., Bai, D., Orser, B.A., and MacDonald, J.F. (2000). Cyclic GMP-dependent feedback inhibition of AMPA receptors is independent of PKG. Nat Neurosci 3, 559-565.
  66. Oliveira-Dos-Santos, A.J., Matsumoto, G., Snow, B.E., Bai, D., Houston, F.P., Whishaw, I.Q., Mariathasan, S., Sasaki, T., Wakeham, A., Ohashi, P.S., Roder, J.C., Barnes, C.A., Siderovski, D.P., and Penninger, J.M. (2000). Regulation of T cell activation, anxiety, and male aggression by RGS2. Proc Natl Acad Sci U S A 97, 12272-12277.
  67. Bai, D., Pennefather, P.S., MacDonald, J.F., and Orser, B.A. (1999). The general anesthetic propofol slows deactivation and desensitization of GABA(A) receptors. J Neurosci 19, 10635-10646.
  68. Bai, D., and Renaud, L.P. (1998). ANG II AT1 receptors induce depolarization and inward current in rat median preoptic neurons in vitro. Am J Physiol 275, R632-639.
  69. Bai, D., and Renaud, L.P. (1998). Median preoptic nucleus neurons: an in vitro patch-clamp analysis of their intrinsic properties and noradrenergic receptors in the rat. Neuroscience 83, 905-916.
  70. Rauh, J.J., Benner, E., Schnee, M.E., Cordova, D., Holyoke, C.W., Howard, M.H., Bai, D., Buckingham, S.D., Hutton, M.L., Hamon, A., Roush, R.T., and Sattelle, D.B. (1997). Effects of [3H]-BIDN, a novel bicyclic dinitrile radioligand for GABA-gated chloride channels of insects and vertebrates. Br J Pharmacol 121, 1496-1505.
  71. Harrison, J.B., Chen, H.H., Sattelle, E., Barker, P.J., Huskisson, N.S., Rauh, J.J., Bai, D., and Sattelle, D.B. (1996). Immunocytochemical mapping of a C-terminus anti-peptide antibody to the GABA receptor subunit, RDL in the nervous system in Drosophila melanogaster. Cell Tissue Res 284, 269-278.
  72. Tornoe, C., Bai, D., Holden-Dye, L., Abramson, S.N., and Sattelle, D.B. (1995). Actions of neurotoxins (bungarotoxins, neosurugatoxin and lophotoxins) on insect and nematode nicotinic acetylcholine receptors. Toxicon 33, 411-424.
  73. Bai, D., and Sattelle, D. (1995). A GABAB receptor on an identified insect motor neurone. J Exp Biol 198, 889-894.
  74. Bai, D., and Sattelle, D.B. (1994). Muscarinic acetylcholine receptors on an identified motor neurone in the cockroach, Periplaneta americana. Neurosci Lett 175, 161-165.
  75. Bai, D., and Sattelle, D.B. (1993). Neosurugatoxin blocks an alpha-bungarotoxin-sensitive neuronal nicotinic acetylcholine receptor. Arch Insect Biochem Physiol 23, 161-167.
  76. Bai, D., Abramson, S.N., and Sattelle, D.B. (1993). Actions of a coral toxin analogue (bipinnatin-B) on an insect nicotinic acetylcholine receptor. Arch Insect Biochem Physiol 23, 155-159.
  77. Wafford, K.A., Bai, D., and Sattelle, D.B. (1992). A novel kainate receptor in the insect nervous system. Neurosci Lett 141, 273-276.
  78. Leech, C.A., Bai, D., and Sattelle, D.B. (1992). A sulphydryl reducing agent, dithiothreitol, modifies agonist-nicotinic receptor interaction in an identified insect neurone. J Exp Biol 169, 267-270.
  79. Bai, D., Erdbrugger, H., Breer, H., and Sattelle, D.B. (1992). Acetylcholine receptors of thoracic dorsal midline neurones in the cockroach, Periplaneta Americana. Arch Insect Biochem Physiol 21, 289-301.
  80. Bai, D., Lummis, S.C.R., Leicht, W., Breer, H., and Sattelle, D.B. (1991). Actions of Imidacloprid and a Related Nitromethylene on Cholinergic Receptors of an Identified Insect Motor-Neuron. Pestic Sci 33, 197-204.
  81. Zhou, P., Lou, L., Bai, D. and Li, J. (1987) The toosendanin induced blocking action of synaptic transmission in the 6th abdominal ganglion of cockroach, Periplaneta americana. ACTA Scientiarum Naturalium Universitatis Pekinesis (2), 1987, 71-76