Rabindra Bhattacharjee
Assistant Professor
MSc (Biochemistry) Dhaka University
PhD (Physiology) Osaka University
Office: LHSC UH B4-234
Phone: (519) 685-8500 Ext. 32207
Fax: (519) 663-3858
E-mail: rbhatta4@uwo.ca
Research Activities
Keywords: drug repositioning in organ preservation, transplant immunity, ischemia reperfusion injury, Toll-like receptor, inflammation
Description of research activities: Our research focuses on the role of innate immune receptor such as Toll-like receptors (TLR) involvement in the pro-inflammatory responses triggered by ischemia reperfusion injury (IRI). IRI continues to be a major concern in transplantation since its occurrence during organ retrieval, subsequent storage in anoxic cold solutions and reestablishment of blood supply post-transplant in the recipient is unavoidable. Our laboratory has successfully developed multiple models of kidney IRI in mouse, porcine and human discard to enable us to design and study modes of intervention to prevent consequent damage. Our research goal is to identify a novel organ preservation method which can protect the organ from damages pre-transplant and promote its optimal function post-transplant. By elucidating the specific immune signaling pathway(s) and repositioning existing drug(s) to prevent IRI-induced inflammation, we target to develop better treatment options for organ preservation to ensure prolonged graft survival in patients with improved quality of life in transplantation.
