The Drug Safety Lab (M.J. Rieder laboratory) is a research lab focused on understanding the molecular pathophysiology of adverse drug reactions (ADRs) for the purpose of developing safe and reliable diagnostic and predictive testing.
The lab has a long experience with in vitro testing for drug hypersensitivity reactions (DHRs, drug allergy) that extends for decades.The hair analysis division of the lab is focused on using hair samples as matrix to measure patient exposure to drugs and endogenous hormones such as cortisol. The latter is used as a marker for stress.We test blood samples from patients and healthy volunteers to aid diagnosis and prediction of DHRs.
The lab also trains number of postdoctoral fellows and graduate students on the use of cutting edge technologies aiming at expanding our knowledge on how small fraction of patients are prone to develop devastating and sometimes lethal ADRs to drugs that are otherwise safe for the majority of the population.
Drug Hypersensitivity Meeting
Amsterdam, The Netherlands
April 19-22, 2018
The Drug Safety Lab on
New test to stop bacteria at factory door
Hair samples provide window into refugee stress
Studying ancient hairs answers questions about stress
Recent publications from the Drug Safety Lab:
- Adverse Drug Reactions in Children: The Double-Edged Sword of Therapeutics. Elzagallaai AA, Greff M, Rieder MJ
- Is the medical use of cannabis a therapeutic option for children? Rieder MJ
- Drug-induced acute kidney injury in children. Faught LN, Greff MJ, Rieder MJ, Koren G.
- In vitro testing for diagnosis of idiosyncratic adverse drug reactions: Implications for pathophysiology. Elzagallaai AA, Rieder MJ.
What is new about drug allergy?
Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.
A case-control genome-wide association study published recently in Neurology 2018 Jan 23;90(4):e332-e341
