Michael Borrie, MD, ChB, FRCPC

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Position: Geriatrician

Office: SJHC, Parkwood Institute, Main Building, 550 Wellington Road, Room A2-129, London, ON, N6C 0A7

Phone: 519.685.4021

Fax: 519.685.4093

E-mail: michael.borrie@sjhc.london.on.ca

 Specialty: Mild Cognitive impairment, Dementia and Geriatric Rehabilitation

 

Dr. Borrie is the Medical Director for the Aging Brain and Memory Clinic, an investigator with the Cognitive Clinical Research Group, and Past President of the Consortium for Canadian Centres for Clinical Cognitive Research (C5R).

Research interests include predictors of conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD), including sensitive biomarkers from neuroimaging techniques, and fluid biomarkers. Our group is supported by funding from the Canadian Institutes of Health Research (CIHR) and National Institutes of Health (NIH) as researchers aligned with the Canadian Collaboration in Neurodegeneration and Aging (CCNA) and the Alzheimer's disease Neuroimaging Initiative (ADNI), respectively.

Since 2013, has been the platform lead for the CCNA Comprehensive Assessment of Neurodegeneration and Aging (COMPASS–ND) study. The Parkwood site is responsible for training and mentoring the 32 Canadian sites for this large observational clinical neuropsychology, MRI, genetic, and biomarker study. It has a recruitment target of 1650 participants who are normal elderly controls, cohorts of people with the subjective cognitive decline (SCD), aMCI, vascular MCI, AD, mixed dementia, frontotemporal dementia, and Parkinson’s disease-related disorders. Our site is one of the seven in The Canadian Therapeutic Platform Trial for Multidomain Interventions to Prevent Dementia (CAN-THUMBS UP). The Parkwood site is the top recruiting site for COMPASS-ND and for the Canadian sites participating in ADNI and its four extensions (2006-present)

The Cognitive Clinical Research Group consists of investigators, clinical trial coordinators, clinicians, and research assistants who research Mild Cognitive Impairment and Alzheimer's disease. As well, we provide education and clinical support to people with cognitive impairment and their families who are in the community.

Our eventual goal is to trial new compounds through randomized controlled trials in people at risk of Alzheimer's disease using neuroimaging biomarkers that could signal support for further development of the studied compounds.

University Held Positions

Professor, Department of Medicine, Geriatrics, Schulich School of Medicine & Dentistry, Western University

Professor, Department of Medicine, Program of Experimental Medicine, Schulich School of Medicine & Dentistry, Western University

PUBLICATIONS


Peer Reviewed Publications

Journal Article

Published

  1. Miracle Ozzoude, Brenda Varriano, Derek Beaton, Joel Ramirez, Sabrina Adamo, Melissa F. Holmes, Christopher J. M. Scott, Fuqiang Gao, Kelly M. Sunderland, Paula McLaughlin, Maged Goubran, Donna Kwan, Angela Roberts, Robert Bartha, Sean Symons, Brian Tan, Richard H. Swartz, Agessandro Abrahao, Gustavo Saposnik, Mario Masellis, Anthony E. Lang, Connie Marras, Lorne Zinman, Christen Shoesmith, Michael Borrie, Corinne E. Fischer, Andrew Frank, Morris Freedman, Manuel Montero-Odasso, Sanjeev Kumar, Stephen Pasternak, Stephen C. Strother, Bruce G. Pollock, Tarek K. Rajji, Dallas Seitz, David F. Tang-Wai, John Turnbull, Dar Dowlatshahi, Ayman Hassan, Leanne Casaubon, Jennifer Mandzia, Demetrios Sahlas, David P. Breen, David Grimes, Mandar Jog, Thomas D. L. Steeves, Stephen R. Arnott, Sandra E. Black, Elizabeth Finger, Jennifer Rabin, ONDRI Investigators & Maria Carmela Tartaglia. White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases. Alz Res Therapy, 2023 Jun 20, Coauthor, DOI: https://doi.org/10.1186/s13195-023-01257-y.
  2. Allison A. Dilliott, Stephanie A. Berberian, Kelly M. Sunderland, Malcolm A. Binns, Julia Zimmer, Miracle Ozzoude, Christopher J.M. Scott, Fuqiang Gao, Anthony E. Lang, David P. Breen, Maria C. Tartaglia, Brian Tan, Richard H. Swartz, Ekaterina Rogaeva, Michael Borrie, Elizabeth Finger, Corinne E. Fischer, Andrew Frank, Morris Freedman, Sanjeev Kumar, Stephen Pasternak, Bruce G. Pollock, Tarek K. Rajji, David F. Tang-Wai, Agessandro Abrahao, John Turnbull, Lorne Zinman, Leanne Casaubon, Dar Dowlatshahi, Ayman Hassan, Jennifer Mandzia, Demetrios Sahlas, Gustavo Saposnik, David Grimes, Connie Marras, Thomas Steeves, Mario Masellis, Sali M.K. Farhan, Robert Bartha, Sean Symons, Robert A. Hegele, Sandra E. Black, Joel Ramirez, ONDRI Investigators. Rare neurovascular genetic and imaging markers across neurodegenerative diseases. J of Alzheimer Association, 2023 Jun 5, Coauthor, DOI: https://doi.org/10.1002/alz.13316.
  3. Wang M, Chekouo T, Ismail Z, Forkert ND, Hogan DB, Ganesh A, Camicioli R, Seitz D, Borrie MJ, Hsiung GR, Masellis M, Moorhouse P, Tartaglia C, Smith EE, Sajobi TT, Alzheimer’s Disease Neuroimaging Initiative. Elicited clinician knowledge did not improve dementia risk prediction in individuals with mild cognitive impairment. J Clin Epidemiol, 2023 Jun 1; 158: 111-118, Coauthor, DOI: 10.1016/j.jclinepi.2023.03.009.
  4. Meng Wang, Tolulope T. Sajobi, David B. Hogan, Aravind Ganesh, Dallas P. Seitz, Thierry Chekouo, Nils D. Forkert, Michael J. Borrie, Richard Camicioli, Ging-Yuek Robin Hsiung, Mario Masellis, Paige Moorhouse, Maria Carmela Tartaglia, Zahinoor Ismail, Eric E. Smith. Expert elicitation of risk factors for progression to dementia in individuals with mild cognitive impairment. J Alzheimer’s Association, 2023 Mar 15, Coauthor, DOI: https://doi.org/10.1002/alz.12987.
  5. Julie Ottoy, Miracle Ozzoude, Katherine Zukotynski, Min Su Kang, Sabrina Adamo, Christopher Scott, Joel Ramirez, Walter Swardfage, Benjamin Lam, Aparna Bhan, Parisa Mojiri, Alex Kiss, Stephen Strother, Christian Bocti, Michael Borrie, Howard Chertkow, Richard Frayne, Robin Hsiung, Robert Jr Laforce, Michael D Noseworthy, Frank S Prato, Demetrios J Sahlas, Eric E Smith, Phillip H Kuo, Jordan A Chad, Ofer Pasternak, Vesna Sossi, Alexander Thiel, Jean-Paul Soucy, Jean-Claude Tardif, Sandra E Black, Maged Goubran, and for the Medical Imaging Trials Network of Canada (MITNEC) and Alzheimer’s Disease Neuroimaging Initiative (ADNI). Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease. Sage Journals, 2023 Jan 25, Coauthor, DOI: https://doi.org/10.1177/0271678X23115200.
  6. Daniel Kapustin, MD , Shadi Zarei, MD, Wei Wang, PhD https://orcid.org/0000-0002-0336-506X, Malcolm A. Binns, PhD, Paula M. McLaughlin, PhD, Agessandro Abrahao, MD, Sandra E. Black, MD, Michael Borrie, MD, David Breen, MD, Leanna Casaubon, MD, Dar Dowlatshahi, MD, Elizabeth Finger, MD, Corinne E Fischer, MD, Andrew Frank, MD, Morris Freedman, MD, David Grimes, MD, Ayman Hassan, MD, Mandar Jog, MD, Donna Kwan, PhD, Anthony Lang, MD, Brian Levine, PhD, Jennifer Mandzia, MD, Connie Marras, MD, Mario Masellis, MD, Joseph B. Orange, PhD, Stephen Pasternak, MD, Alicia Peltsch, PhD, Bruce G. Pollock, MD, Tarek K. Rajji, MD, Angela Roberts, PhD, Demetrios Sahlas, MD, Gustavo Saposnik, MD, Dallas Seitz, MD, Christen Shoesmith, MD, Alisia Southwell, HBSc, Thomas D.L. Steeves, MD, Kelly Sunderland, MSc, Richard H Swartz, MD, Brian Tan, MSc, David F. Tang-Wai, MD, Maria Carmela Tartaglia, MD, Angela Troyer, PhD, John Turnbull, MD, Lorne Zinman, MD, the ONDRI investigators and Sanjeev Kumar. Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function. Can J Psychiatry, 2023 Jan 13, Coauthor, DOI: https://doi.org/10.1177/07067437221147443.
  7. Sunderland KM, Beaton D, Arnott SR, Kleinstiver P, Kwan D, Lawrence-Dewar JM, Ramirez J, Tan B, Bartha R, Black SE, Borrie M, Brien D, Casaubon LK, Coe BC, Cornish B, Dilliott AA, Dowlatshahi D, Finger E, Fischer C, Frank A, Fraser J, Freedman M, Greenberg B, Grimes DA, Hassan A, Hatch W, Hegele RA, Hudson C, Jog M, Kumar S, Lang A, Levine B, Lou W, Mandzia J, Marras C, McIlroy W, Montero-Odasso M, Munoz DG, Munoz DP, Orange JB, Park DS, Pasternak SH, Pieruccini-Faria F, Rajji TK, Roberts AC, Robinson JF, Rogaeva E, Sahlas DJ, Saposnik G, Scott CJM, Seitz D, Shoesmith C, Steeves TDL, Strong MJ, Strother SC, Swartz RH, Symons S, Tang-Wai DF, Tartaglia MC, Troyer AK, Turnbull J, Zinman L, McLaughlin PM, Masellis M, Binns MA, ONDRI Investigators. Characteristics of the Ontario Neurodegenerative Disease Research Initiative cohort. Alzheimers Dement, 2023 Jan 1; 19 (1): 226-243, Coauthor, DOI: 10.1002/alz.12632.
  8. Lucas M Crawford-Holland, Jennifer S. Rabin, Luis R Fornazzari, Tom A. Schweizer, Corinne E. Fischer, David G. Munoz, Sanjeev Kumar, Sandra E. Black, Morris Freedman, Michael Borrie, Andrew R Frank, Stephen H Pasternak, Bruce G. Pollock, Tarek K. Rajji, Dallas Seitz, David F. Tang-Wai, Carmela Tartaglia, Donna Kwan, Brian Tan. Smoking Gun? Effect of smoking history on cognition in AD and MCI. Alzheimers Dement, 2022 Dec 20, Coauthor, DOI: https://doi.org/10.1002/alz.068722.
  9. Ottoy J, Ozzoude M, Zukotynski K, Adamo S, Scott C, Gaudet V, Ramirez J, Swardfager W, Cogo-Moreira H, Lam B, Bhan A, Mojiri P, Kang MS, Rabin JS, Kiss A, Strother S, Bocti C, Borrie M, Chertkow H, Frayne R, Hsiung R, Laforce RJ, Noseworthy MD, Prato FS, Sahlas DJ, Smith EE, Kuo PH, Sossi V, Thiel A, Soucy JP, Tardif JC, Black SE, Goubran M, Medical Imaging Trial Network of Canada (MITNEC) and Alzheimer’s Disease Neuroimaging Initiative (ADNI). Vascular burden and cognition: Mediating roles of neurodegeneration and amyloid PET. Alzheimers Dement, 2022 Sep 1, Coauthor, DOI: 10.1002/alz.12750.
  10. Dilliott AA, Zhang KK, Wang J, Abrahao A, Binns MA, Black SE, Borrie M, Dowlatshahi D, Finger E, Fischer CE, Frank A, Freedman M, Grimes D, Hassan A, Jog M, Kumar S, Lang AE, Mandzia J, Masellis M, Pasternak SH, Pollock BG, Rajji TK, Rogaeva E, Sahlas DJ, Saposnik G, Sato C, Seitz D, Shoesmith C, Steeves TDL, Swartz RH, Tan B, Tang-Wai DF, Tartaglia MC, Turnbull J, Zinman L, ONDRI Investigators. Hegele RA. Targeted copy number variant identification across the neurodegenerative disease spectrum. Mol Genet Genomic Med, 2022 Aug 1; 10 (8): e1986, Coauthor, DOI: 10.1002/mgg3.1986.
  11. Beaton D, McLaughlin PM, Orange JB, Munoz DP, Mandzia J, Abrahao A, Binns MA, Black SE, Borrie M, Dowlatshahi D, Freedman M, Fischer CE, Finger EC, Frank A, Grimes D, Hassan A, Kumar S, Lang AE, Levine B, Marras C, Masellis M, Pollock BG, Rajji TK, Ramirez J, Sahlas DJ, Saposnik G, Scott CJM, Seitz DP, Strother SC, Sunderland KM, Tan B, Tang-Wai DF, Troyer AK, Turnbull J, Zinman L, Swartz RH, Tartaglia MC, Breen DP, Kwan D, Roberts AC, The Ondri Investigators. Caregiving concerns and clinical characteristics across neurodegenerative and cerebrovascular disorders in the Ontario neurodegenerative disease research initiative. Int J Geriatr Psychiatry, 2022 Jun 1; 37 (6), Coauthor, DOI: 10.1002/gps.5727.
  12. Ozzoude M, Varriano B, Beaton D, Ramirez J, Holmes MF, Scott CJM, Gao F, Sunderland KM, McLaughlin P, Rabin J, Goubran M, Kwan D, Roberts A, Bartha R, Symons S, Tan B, Swartz RH, Abrahao A, Saposnik G, Masellis M, Lang AE, Marras C, Zinman L, Shoesmith C, Borrie M, Fischer CE, Frank A, Freedman M, Montero-Odasso M, Kumar S, Pasternak S, Strother SC, Pollock BG, Rajji TK, Seitz D, Tang-Wai DF, Turnbull J, Dowlatshahi D, Hassan A, Casaubon L, Mandzia J, Sahlas D, Breen DP, Grimes D, Jog M, Steeves TDL, Arnott SR, Black SE, Finger E, ONDRI Investigators. Tartaglia MC. Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases. Geroscience, 2022 Jun 1; 44 (3): 1575-1598, Coauthor, DOI: 10.1007/s11357-022-00539-x.
  13. Milicic L, Vacher M, Porter T, Doré V, Burnham SC, Bourgeat P, Shishegar R, Doecke J, Armstrong NJ, Tankard R, Maruff P, Masters CL, Rowe CC, Villemagne VL, Laws SM, Alzheimer’s Disease Neuroimaging Initiative (ADNI). Australian Imaging Biomarkers and Lifestyle (AIBL) Study. Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume. Geroscience, 2022 Jun 1; 44 (3): 1807-1823, Collaborator, DOI: 10.1007/s11357-022-00558-8.
  14. Jiang J, Sheng C, Chen G, Liu C, Jin S, Li L, Jiang X, Han Y, Alzheimer’s Disease Neuroimaging Initiative. Glucose metabolism patterns: A potential index to characterize brain ageing and predict high conversion risk into cognitive impairment. Geroscience, 2022 May 18, Collaborator, DOI: 10.1007/s11357-022-00588-2.
  15. Wen J, Fu CHY, Tosun D, Veturi Y, Yang Z, Abdulkadir A, Mamourian E, Srinivasan D, Skampardoni I, Singh A, Nawani H, Bao J, Erus G, Shou H, Habes M, Doshi J, Varol E, Mackin RS, Sotiras A, Fan Y, Saykin AJ, Sheline YI, Shen L, Ritchie MD, Wolk DA, Albert M, Resnick SM, Davatzikos C, iSTAGING consortium, ADNI, BIOCARD, and BLSA. Characterizing Heterogeneity in Neuroimaging, Cognition, Clinical Symptoms, and Genetics Among Patients With Late-Life Depression. JAMA Psychiatry, 2022 May 1; 79 (5): 464-474, Collaborator, DOI: 10.1001/jamapsychiatry.2022.0020.
  16. Duong MT, Das SR, Lyu X, Xie L, Richardson H, Xie SX, Yushkevich PA, Alzheimer’s Disease Neuroimaging Initiative (ADNI). Wolk DA, Nasrallah IM. Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer’s disease. Nat Commun, 2022 Mar 21; 13 (1): 1495, Collaborator, DOI: 10.1038/s41467-022-28941-1.
  17. Seyyed Mohammad Hassan Haddad, Christopher J.M. Scott, Stephen R. Arnott, Miracle Ozzoude, Stephen C. Strother, Sandra E. Black, Michael Borrie, Elizabeth Finger, Maria Carmela Trataglia, Donna Kwan, Derek Beaton, Sean Symons, Andrea Soddu, Ravi S. Menon, Manuel Montero-Odasso, Robert Bartha. Comparison of neuronal activity profiles in Alzheimer’s disease and frontotemporal dementia measured by resting-state fMRI. J Alzheimer’s Association, 2022 Feb 1, Coauthor, DOI: https://doi.org/10.1002/alz.054549.
  18. Inglese M, Patel N, Linton-Reid K, Loreto F, Win Z, Perry RJ, Carswell C, Grech-Sollars M, Crum WR, Lu H, Malhotra PA, Alzheimer’s Disease Neuroimaging Initiative. Aboagye EO. A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease. Commun Med (Lond), 2022 Jan 1; 2: 70, Collaborator, DOI: 10.1038/s43856-022-00133-4.
  19. Yang Z, Caldwell JZK, Cummings JL, Ritter A, Kinney JW, Cordes D, Alzheimer’s Disease Neuroimaging Initiative (ADNI). Sex Modulates the Pathological Aging Effect on Caudate Functional Connectivity in Mild Cognitive Impairment. Front Psychiatry, 2022 Jan 1; 13: 804168, Collaborator, DOI: 10.3389/fpsyt.2022.804168.
  20. Julie Ottoy,Miracle Ozzoude,Katherine Zukotynski,Sabrina M. Adamo,Christopher J. M. Scott,Vincent Gaudet,Joel Ramirez,Walter Swardfager,Benjamin Lam,Aparna Bhan,Alex Kiss,Stephen C. Strother,Christian Bocti,Michael Borrie,Howard Chertkow,Richard Frayne,Ging-Yuek Robin Hsiung,Robert Laforce Jr.Michael D. Noseworthy,Frank S. Prato,Demetrios J. Sahlas,Eric E. Smith,Vesna Sossi,Alexander Thiel,Jean-Paul Soucy,Jean-Claude Tardif,Maged Goubran,Sandra E. Black. Amyloid-independent vascular contributions to cortical atrophy and cognition in a multi-center mixed cohort with low to severe small vessel disease. J Alzheimer’s Association, 2021 Dec 31, Coauthor, DOI: https://doi.org/10.1002/alz.056326.
  21. Yang Z, Nasrallah IM, Shou H, Wen J, Doshi J, Habes M, Erus G, Abdulkadir A, Resnick SM, Albert MS, Maruff P, Fripp J, Morris JC, Wolk DA, Davatzikos C, iSTAGING Consortium. Baltimore Longitudinal Study of Aging (BLSA). Alzheimer’s Disease Neuroimaging Initiative (ADNI). A deep learning framework identifies dimensional representations of Alzheimer’s Disease from brain structure. Nat Commun, 2021 Dec 3; 12 (1): 7065, Collaborator, DOI: 10.1038/s41467-021-26703-z.
  22. Chertkow H, Rockwood K, Hogan DB, Phillips N, Montero-Odasso M, Amanullah S, Black S, Bocti C, Borrie M, Feldman H, Freedman M, Hsiung R, Kirk A, Masellis M, Nygaard H, Rajji T, Verret L. Consensus Statement Regarding the Application of Biogen to Health Canada for Approval of Aducanumab. Can Geriatr J, 2021 Dec 1; 24 (4): 373-378, Coauthor, DOI: 10.5770/cgj.24.570.
  23. Shen XN, Huang YY, Chen SD, Guo Y, Tan L, Dong Q, Yu JT, Alzheimer’s Disease Neuroimaging Initiative. Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status. Transl Psychiatry, 2021 Nov 13; 11 (1): 585, Collaborator, DOI: 10.1038/s41398-021-01709-9.
  24. Das SR, Lyu X, Duong MT, Xie L, McCollum L, de Flores R, DiCalogero M, Irwin DJ, Dickerson BC, Nasrallah IM, Yushkevich PA, Wolk DA, Alzheimer’s Disease Neuroimaging Initiative. Tau-Atrophy Variability Reveals Phenotypic Heterogeneity in Alzheimer’s Disease. Ann Neurol, 2021 Nov 1; 90 (5): 751-762, Collaborator, DOI: 10.1002/ana.26233.
  25. Dilliott AA, Abdelhady A, Sunderland KM, Farhan SMK, Abrahao A, Binns MA, Black SE, Borrie M, Casaubon LK, Dowlatshahi D, Finger E, Fischer CE, Frank A, Freedman M, Grimes D, Hassan A, Jog M, Kumar S, Kwan D, Lang AE, Mandzia J, Masellis M, McIntyre AD, Pasternak SH, Pollock BG, Rajji TK, Rogaeva E, Sahlas DJ, Saposnik G, Sato C, Seitz D, Shoesmith C, Steeves TDL, Swartz RH, Tan B, Tang-Wai DF, Tartaglia MC, Turnbull J, Zinman L, ONDRI Investigators. Hegele RA. Contribution of rare variant associations to neurodegenerative disease presentation. NPJ Genom Med, 2021 Sep 28; 6 (1): 80, Coauthor, DOI: 10.1038/s41525-021-00243-3.
  26. Chen SD, Lu JY, Li HQ, Yang YX, Jiang JH, Cui M, Zuo CT, Tan L, Dong Q, Yu JT, Alzheimer’s Disease Neuroimaging Initiative. Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study. Transl Psychiatry, 2021 Sep 18; 11 (1): 483, Collaborator, DOI: 10.1038/s41398-021-01602-5.
  27. Gonneaud J, Baria AT, Pichet Binette A, Gordon BA, Chhatwal JP, Cruchaga C, Jucker M, Levin J, Salloway S, Farlow M, Gauthier S, Benzinger TLS, Morris JC, Bateman RJ, Breitner JCS, Poirier J, Vachon-Presseau E, Villeneuve S, Alzheimer’s Disease Neuroimaging Initiative (ADNI). Dominantly Inherited Alzheimer Network (DIAN) Study Group. Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group. Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease. Nat Commun, 2021 Sep 9; 12 (1): 5346, Collaborator, DOI: 10.1038/s41467-021-25492-9.
  28. Basu M, Cooper T, Kay K, Hogan DB, Morais JA, Molnar F, Lam RE, Borrie MJ. Updated Inventory and Projected Requirements for Specialist Physicians in Geriatrics. Can Geriatr J, 2021 Sep 1; 24 (3): 200-208, Senior Responsible Author, DOI: 10.5770/cgj.24.538.
  29. Chung Y, Lee H, the Alzheimer’s Disease Neuroimaging Initiative. Correlation between Alzheimer’s disease and type 2 diabetes using non-negative matrix factorization. Sci Rep, 2021 Jul 27; 11 (1): 15265, Collaborator, DOI: 10.1038/s41598-021-94048-0.
  30. Ramirez J, Holmes MF, Berezuk C, Kwan D, Tan B, Beaton D, Scott CJM, Ozzoude M, Gao F, Yu D, Swardfager W, Lawrence-Dewar J, Dowlatshahi D, Saposnik G, Boulos MI, Murray BJ, Symons S, Bartha R, Black SE, Swartz RH, ONDRI Investigators. Lim A. MRI-visible perivascular space volumes, sleep duration and daytime dysfunction in adults with cerebrovascular disease. Sleep Med, 2021 Jul 1; 83: 83-88, Collaborator, DOI: 10.1016/j.sleep.2021.03.043.
  31. Hu WT, Ozturk T, Kollhoff A, Wharton W, Christina Howell J, Alzheimer’s Disease Neuroimaging Initiative. Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease. Nat Commun, 2021 Jun 28; 12 (1): 4001, Collaborator, DOI: 10.1038/s41467-021-24220-7.
  32. Neitzel J, Franzmeier N, Rubinski A, Dichgans M, Brendel M, Alzheimer’s Disease Neuroimaging Initiative (ADNI). Malik R, Ewers M. KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease. Nat Commun, 2021 Jun 22; 12 (1): 3825, Collaborator, DOI: 10.1038/s41467-021-23755-z.
  33. Vogel JW, Young AL, Oxtoby NP, Smith R, Ossenkoppele R, Strandberg OT, La Joie R, Aksman LM, Grothe MJ, Iturria-Medina Y, Alzheimer’s Disease Neuroimaging Initiative. Pontecorvo MJ, Devous MD, Rabinovici GD, Alexander DC, Lyoo CH, Evans AC, Hansson O. Four distinct trajectories of tau deposition identified in Alzheimer’s disease. Nat Med, 2021 May 1; 27 (5): 871-881, Collaborator, DOI: 10.1038/s41591-021-01309-6.
  34. Dilliott AA, Sunderland KM, McLaughlin PM, Roberts AC, Evans EC, Abrahao A, Binns MA, Black SE, Borrie M, Casaubon LK, Dowlatshahi D, Finger E, Fischer CE, Frank A, Freedman M, Grimes D, Hassan A, Jog M, Kumar S, Kwan D, Lang AE, Mandzia J, Marras C, Masellis M, McIntyre AD, Pasternak S, Pollock BG, Rajji TK, Robinson JF, Rogaeva E, Sahlas DJ, Saposnik G, Sato C, Seitz D, Shoesmith C, Steeves T, Strother SC, Swartz RH, Tan B, Tang-Wai D, Tartaglia MC, Troyer AK, Turnbull J, Zinman L, ONDRI Investigators. Hegele RA. Association of apolipoprotein E variation with cognitive impairment across multiple neurodegenerative diagnoses. Neurobiol Aging, 2021 Apr 24, Coauthor, DOI: 10.1016/j.neurobiolaging.2021.04.011.
  35. Harerimana B, Forchuk C, Walsh J, Fogarty J, Borrie M. Brain Health: A Concept Analysis. Issues Ment Health Nurs, 2021 Feb 1; 42 (2): 145-152, Senior Responsible Author, DOI: 10.1080/01612840.2020.1789781.
  36. Smith EE, Duchesne S, Gao F, Saad F, Whitehead V, McCreary CR, Frayne R, Gauthier S, Camicioli R, Borrie M, Black SE. Vascular Contributions to Neurodegeneration: Protocol of the COMPASS-ND Study. Can J Neurol Sci, 2021 Jan 28: 1-23, Coauthor, DOI: 10.1017/cjn.2021.19.
  37. Liang S, Beaton D, Arnott SR, Gee T, Zamyadi M, Bartha R, Symons S, MacQueen GM, Hassel S, Lerch JP, Anagnostou E, Lam RW, Frey BN, Milev R, Müller DJ, Kennedy SH, Scott CJM, ONDRI Investigators. Strother SC. Magnetic Resonance Imaging Sequence Identification Using a Metadata Learning Approach. Front Neuroinform, 2021 Jan 1; 15: 622951, Collaborator, DOI: 10.3389/fninf.2021.622951.
  38. Franzmeier N, Suárez-Calvet M, Frontzkowski L, Moore A, Hohman TJ, Morenas-Rodriguez E, Nuscher B, Shaw L, Trojanowski JQ, Dichgans M, Kleinberger G, Haass C, Ewers M, Alzheimer’s Disease Neuroimaging Initiative (ADNI). Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration. Mol Neurodegener, 2020 Oct 8; 15 (1): 57, Collaborator, DOI: 10.1186/s13024-020-00407-2.
  39. Teipel SJ, Fritz HC, Grothe MJ, Alzheimer’s Disease Neuroimaging Initiative. Neuropathologic features associated with basal forebrain atrophy in Alzheimer disease. Neurology, 2020 Sep 8; 95 (10): e1301-e1311, Collaborator, DOI: 10.1212/WNL.0000000000010192.
  40. Michael J. Borrie, Tracy Cooper, Monisha Basu, Kelly Kay, Jeannette C. Prorok, Dallas Seitz. Ontario Geriatric Specialist Physician Resources 2018. Canadian Geriatrics Journal, 2020 Sep; 23 (3): 245-253, Principal Author, DOI: 10.5770/cgj.23.448.
  41. Fotiadis P, Reijmer YD, Van Veluw SJ, Martinez-Ramirez S, Karahanoglu FI, Gokcal E, Schwab KM, Alzheimer’s Disease Neuroimaging Initiative study group. Goldstein JN, Rosand J, Viswanathan A, Greenberg SM, Gurol ME. White matter atrophy in cerebral amyloid angiopathy. Neurology, 2020 Aug 4; 95 (5): e554-e562, Collaborator, DOI: 10.1212/WNL.0000000000010017.
  42. Squillario M, Abate G, Tomasi F, Tozzo V, Barla A, Uberti D, Alzheimer’s Disease Neuroimaging Initiative. A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer’s disease. Sci Rep, 2020 Jul 21; 10 (1): 12063, Collaborator, DOI: 10.1038/s41598-020-67699-8.

 

 

Michael Borrie, MB ChB, FRCPC is a Geriatrician and Professor in the Department of Medicine, Division of Geriatric Medicine, Western University. He was an MRC (New Zealand) Training Research Fellow 1983-1985 in Dunedin, New Zealand. He completed his training in Internal Medicine in Edmonton, Alberta and in Geriatric Medicine in London, Ontario.