Matthew Maitland
Matthew Maitland is currently a PhD candidate at Robarts Research Institute and the Department of Biochemistry, Western University under the co-supervision of Dr. Caroline Schild-Poulter and Dr. Gilles Lajoie. His research is focused on understanding the molecular mechanisms of how Ran Binding Protein M (RanBPM) regulates oncogenic signaling pathways and prevents tumourigenesis. RanBPM is a core member of the CTLH complex, a putative E3 ubiquitin ligase. The function of this complex in mammalian cells is completely unknown. Using molecular biology and proteomic-based mass spectronomy techniques, this project is characterizing the structure and function of the CTLH complex and identifying its ubiquitination targets in cancer cells. Overall, the aim of this project is to characterize a novel E3 ubiquitin ligase and uncover new regulatory mechanisms of oncogenic signalling that could be exploited in targeted therapies for cancer patients.
